Afstyla (recombinant)

Generic name: antihemophilic factor (recombinant) [ ant-ee-hee-moe-FIL-ik-FAK-tor ]
Brand names: Advate, Adynovate, Afstyla, Eloctate with Fc Fusion Protein, Esperoct, ... show all 14 brands Helixate FS, Jivi, Kogenate FS, Kogenate FS with Adapter, Kovaltry, Novoeight, Nuwiq, Recombinate, Xyntha
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by Drugs.com on Apr 6, 2022. Written by Cerner Multum.

What is recombinant Afstyla?

Afstyla (clotting factor) is a naturally occurring protein in the blood. People with hemophilia A have a deficiency in clotting factor VIII. Recombinant this medicine replaces clotting factor VIII in the blood.

Recombinant Afstyla is used to treat or prevent bleeding episodes in adults and children with hemophilia A. Afstyla is sometimes given before a surgery.

Recombinant Afstyla can help prevent joint damage in children who have hemophilia A and no prior joint damage.

Recombinant Afstyla is not for use in treating von Willebrand disease.

Jivi is not approved for use by anyone younger than 12 years old.

Recombinant Afstyla may also be used for purposes not listed in this medication guide.

Warnings

Carefully follow all instructions about how to mix and store this medicine. Different brands of recombinant Afstyla may have different storage instructions.

Your body may develop antibodies to Afstyla, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

Before taking this medicine

You should not use Afstyla if you have ever had a severe allergic reaction to Afstyla, or if you are allergic to mouse or hamster proteins. You should not use the brand Recombinate if you are allergic to beef proteins.

Tell your doctor if you have ever had:

• heart disease;

• a latex allergy; or

• if you have ever been told that you have inhibitors to Factor VIII.

Tell your doctor if you are pregnant or breastfeeding.

How should I use recombinant Afstyla?

Your doctor will perform a blood test to make sure recombinant Afstyla is the right treatment for your clotting factor deficiency.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your doctor may occasionally change your dose. Always check the strength of the medicine on the label to be sure you are using the correct potency.

Recombinant Afstyla is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Recombinant Afstyla must be mixed with a liquid (diluent) before using it. Ask your doctor or pharmacist if you don''t understand how to properly mix and store the medicine.

Always wash your hands before preparing and giving your injection.

Prepare an injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Recombinant Afstyla doses are based on weight. Your dose needs may change if you gain or lose weight.

You will need frequent medical tests.

Your body may develop antibodies to Afstyla, making it less effective. Call your doctor if this medicine seems to be less effective in controlling your bleeding.

Get your prescription refilled before you run out of medicine completely. While traveling away from home, be sure you have enough medicine and injection supplies with you.

Store unmixed recombinant Afstyla in the original package in a refrigerator. Do not freeze. Take the medicine out of the refrigerator and let it reach room temperature before preparing your dose.

You may also store unmixed recombinant Afstyla at room temperature, but you must not return it to the refrigerator. Some brands of this medicine can be stored at room temperature for only a certain number of months, or until the expiration date (whichever comes first).

Carefully follow all instructions about how to store this medicine. Different brands of recombinant Afstyla may have different storage instructions.

Do not store in bright light. Do not use past the expiration date on the label.

After mixing the medicine and diluent, keep the mixture at room temperature (not in a refrigerator) and use it within 3 hours.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

In case of emergency, wear or carry medical identification to let others know you have a bleeding or blood-clotting disorder.

What happens if I miss a dose?

Since recombinant Afstyla is used when needed, you may not be on a routine dosing schedule. However, you may need to use the medicine for several days in a row to control a bleeding episode. Keep using the medicine as directed and tell your doctor if your bleeding continues.

Use any missed dose as soon as you remember. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using recombinant Afstyla?

Follow your doctor''s instructions about any restrictions on food, beverages, or activity.

Recombinant Afstyla side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, rash, numbness, tingling; fever, dizziness, nausea; fast heartbeats, chest tightness, wheezing, difficult breathing; pale skin, cold sweat, feeling light-headed, fainting; swelling of your face, lips, tongue, or throat.

Afstyla may cause serious side effects. Call your doctor at once if you have:

• increased bleeding episodes;

• any bleeding that will not stop;

• chest pain; or

• a light-headed feeling, like you might pass out.

Common side effects of Afstyla may include:

• nose bleeds;

• nausea, vomiting, diarrhea;

• headache, dizziness;

• muscle or joint pain;

• rash;

• flushing (sudden warmth, redness, or tingly feeling);

• fever, chills;

• cough;

• weakness; or

• pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect recombinant Afstyla?

Other drugs may affect recombinant Afstyla, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 10.01.

Aftate (Topical)

Generic name: tolnaftate (topical route) [ tol-NAF-tate ]
Drug class: Topical antifungals

Medically reviewed by Drugs.com. Last updated on Jan 11, 2023.

Commonly used brand name(s)

In the U.S.

• Absorbine Jr. Antifungal
• Aftate
• Blis-To-Sol
• Dermasept Antifungal
• Fungi-Guard
• Podactin
• Q-Naftate
• Tinactin
• Tinaderm
• Ting

In Canada

• Athlete''s Foot Gel
• Dr. Scholl''s Athlete''s Foot
• Pitrex
• Scholl''s Athlete''s Foot Spray
• Scholl Tritin Antifungal Powder
• Scholl Tritin Antifungal Spray Powder
• Tinactin Aerosol Liquid
• Tinactin Aerosol Powder
• Tinactin Jock Itch
• Tinactin Plus
• Tinactin Plus Aerosol Powder

Available Dosage Forms:

• Spray
• Cream
• Powder
• Solution

Therapeutic Class: Antifungal

Uses for Aftate

Tolnaftate belongs to the group of medicines called antifungals. It is used to treat some types of fungus infections. It may also be used together with medicines taken by mouth for fungus infections.

Tolnaftate is available without a prescription.

Before using Aftate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Tolnaftate should not be used on children up to 2 years of age, unless otherwise directed by your doctor. Although there is no specific information comparing use of tolnaftate in children 2 years of age and older with use in other age groups, this medicine is not expected to cause different side effects or problems in children 2 years of age and older than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tolnaftate in the elderly with use in other age groups.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of Aftate

This section provides information on the proper use of a number of products that contain tolnaftate. It may not be specific to Aftate. Please read with care.

Before applying tolnaftate, wash the affected area and dry thoroughly. Then apply enough medicine to cover the affected area.

Keep this medicine away from the eyes.

For patients using the powder form of this medicine:

• If the powder is used on the feet, sprinkle it between toes, on feet, and in socks and shoes.

For patients using the aerosol powder form of this medicine:

• Shake well before using.
• From a distance of 6 to 10 inches, spray the powder on the affected areas. If it is used on the feet, spray it between toes, on feet, and in socks and shoes.
• Do not inhale the powder.
• Do not use near heat, near open flame, or while smoking.

For patients using the solution form of this medicine:

• If tolnaftate solution becomes a solid, it may be dissolved by warming the closed container of medicine in warm water.

For patients using the aerosol solution form of this medicine:

• Shake well before using.
• From a distance of 6 inches, spray the solution on the affected areas. If it is used on the feet, spray between toes and on feet.
• Do not inhale the vapors from the spray.
• Do not use near heat, near open flame, or while smoking.

To help clear up your infection completely, keep using this medicine for 2 weeks after burning, itching, or other symptoms have disappeared , unless otherwise directed by your doctor. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor''s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For topical dosage forms (aerosol powder, aerosol solution, cream, gel, powder, or topical solution):
  • For fungus infections:
    • Adults and children 2 years of age and over—Apply to the affected area(s) of the skin two times a day.
    • Children up to 2 years of age—Use is not recommended except under the advice and supervision of your doctor.

Missed dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions while using Aftate

If your skin problem does not improve within 4 weeks, or if it becomes worse, check with your health care professional.

To help prevent reinfection after the period of treatment with this medicine, the powder or spray powder form of this medicine may be used each day after bathing and carefully drying the affected area.

Aftate side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Skin irritation not present before use of this medicine

When you apply the aerosol solution form of this medicine, a mild temporary stinging may be expected.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer