Description:

Zyrtec-D (Oral)

Generic name: cough and cold combinations (oral route)

Commonly used brand name(s)

In the U.S.

Ala-Hist AC
Ala-Hist DHC
Alavert-D 12-Hour
Aldex D
Alka-Seltzer Plus Cold and Sinus
AllanVan-S
Allegra
Allegra-D
Aller-Chlor
Allerx-D
Allfen CD
Allres PD
Amibid LA
Benadryl
BPM Pseudo
Bromcomp HC
Bromfed-PD
BroveX CB
By-Ache
Canges-HC
Ceron
Ceron-DM
Chlor-Trimeton Nasal Decongestant
Clarinex-D
Codimal DH
Cotab A
Cotabflu
Cypex-LA
Deconamine SR
Delsym
Dexphen w/C
Donatussin DC
Donnatussin
D-Tann HC
EndaCof-DC
FluTuss XP
Genapap Sinus
G Phen DM
HC Tussive
Histex PD
Humibid DM
Hycodan
Hycofenix
Hydone
HyTan
Kie
Levall 12
Lusonal
Maxiflu CD
Maxiphen CD
M-End Max D
Mucinex D
Nasop
Notuss-Forte
Notuss-NX
Notuss-NXD
Novahistine DH
Pancof HC
Pediatex 12
Pediatex 12D
Pediatex 12DM
Pediatex-D
Phenergan w/Codeine
Phenflu CD
Phenylephrine CM
Phenylhistine
Poly-Tussin AC
Poly-Tussin DHC
Pro-Clear AC
Promethazine VC With Codeine
Pro-Red AC
RelaTuss HC
Robitussin
Robitussin DM
Ryneze
Semprex-D
SSKI
Stahist
Sudafed
SymTan
SymTan A
Tanafed DMX
Tannate Pediatric
Tessalon Perles
Triacin C
Tricold Pediatric Drops
Tripohist D
Tussi-12 S
TussiCaps
Tuzistra XR
Tylenol
Uni-Tann D
Vituz
Xpect-PE
Xyzal
Y-Cof DM
Z-COF DM
Zhist
Zodryl DAC 25
Zotex-D
Zymine
Zymine HC
ZyrTEC-D

In Canada

Actifed Sinus Regular
Adult Nighttime Cold/Flu Relief - Cherry Flavor
Adult Nighttime Cold/Flu Relief - Original Flavor
Allergy Sinus Medication Extra Strength
Atoma Night Adult Cold/Flu Relief
Atoma Nighttime Cold/Flu Relief - Cherry Flavor
Balminil
Balminil Dm Children
Balminil Dm Sugar-Free
Balminil Expectorant
Balminil Expectorant Sugar-Free
Balminil With Sugar

Available Dosage Forms:

Solution
Tablet, Chewable
Tablet, Extended Release, 24 HR
Tablet, Extended Release
Tablet, Extended Release, 12 HR
Tablet
Syrup
Liquid
Capsule, Liquid Filled
Capsule
Elixir
Suspension, Extended Release
Lozenge/Troche
Suspension
Tablet, Effervescent
Packet
Powder for Solution
Film

Uses for Zyrtec-D

Cough/cold combinations are used mainly to relieve the cough due to colds, influenza, or hay fever. They are not to be used for the chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (pronounced flem) with the cough.

Cough/cold combination products contain more than one ingredient. For example, some products may contain an antihistamine, a decongestant, and an analgesic, in addition to a medicine for coughing. If you are treating yourself, it is important to select a product that is best for your symptoms. Also, in general, it is best to buy a product that includes only those medicines you really need. If you have questions about which product to buy, check with your pharmacist.

Since different products contain ingredients that will have different precautions and side effects, it is important that you know the ingredients of the medicine you are taking. The different kinds of ingredients that may be found in cough/cold combinations include:

Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Some examples of antihistamines contained in these combinations are:

Bromodiphenhydramine
Brompheniramine
Carbinoxamine
Chlorpheniramine
Dexchlorpheniramine
Diphenhydramine
Doxylamine
Phenindamine
Pheniramine
Phenyltoloxamine
Pyrilamine
Promethazine
Triprolidine

Decongestants—Decongestants produce a narrowing of blood vessels. This leads to clearing of nasal congestion. However, this effect may also increase blood pressure in patients who have high blood pressure. These include:

Ephedrine
Phenylephrine
Pseudoephedrine

Antitussives—Antitussives help relieve coughing and are some contain a narcotic. These antitussives act directly on the cough center in the brain. Narcotics may become habit-forming, causing mental or physical dependence, if used for a long time. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Codeine
Dihydrocodeine
Hydrocodone
Hydromorphone

Carbetapentane
Caramiphen
Dextromethorphan

Expectorants—Expectorants work by loosening the mucus or phlegm in the lungs. The main expectorant used in cough and cold medicines is guaifenesin. Other ingredients added as expectorants (for example, ammonium chloride, calcium iodide, iodinated glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium citrate) have not been proven to be effective. In general, the best thing you can do to loosen mucus or phlegm is to drink plenty of water.

Analgesics—Analgesics are used in these combination medicines to help relieve the aches and pain that may occur with the common cold. These include:

Acetaminophen
Aspirin
Other salicylates such as salicylamide and sodium salicylate

The use of too much acetaminophen and salicylates at the same time may cause kidney damage or cancer of the kidney or urinary bladder. This may occur if large amounts of both medicines are taken together for a long time. However, taking the recommended amounts of combination medicines that contain both acetaminophen and a salicylate for short periods of time has not been shown to cause these unwanted effects.

Anticholinergics—Anticholinergics, such as homatropine may help produce a drying effect in the nose and chest.

These cough and cold combinations are available both over-the-counter (OTC) and with your doctor''s prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Before using Zyrtec-D

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Very young children are usually more sensitive to the effects of this medicine. Before giving any of these combination medicines to a child, check the package label very carefully. Some of these medicines are too strong for use in children. If you are not certain whether a specific product can be given to a child, or if you have any questions about the amount to give, check with your health care professional, especially if it contains:

Antihistamines—Nightmares, unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children taking antihistamines.
Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Increases in blood pressure may be more likely to occur in children taking decongestants.
Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby.
Narcotic antitussives (e.g., codeine, dihydrocodeine, hydrocodone, and hydromorphone)—Breathing problems may be especially likely to occur in children younger than 2 years of age taking narcotic antitussives. Also, unusual excitement or restlessness may be more likely to occur in children receiving these medicines.
Salicylates (e.g., aspirin)—Do not give medicines containing aspirin or other salicylates to a child or teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child''s doctor. This is very important because salicylates may cause a serious illness called Reye''s syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Also, children may be more sensitive to the aspirin or other salicylates contained in some of these medicines, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating.

Geriatric

The elderly are usually more sensitive to the effects of this medicine, especially if it contains:

Antihistamines—Confusion, difficult or painful urination, dizziness, drowsiness, feeling faint, or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in the elderly taking antihistamines.
Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Confusion, hallucinations, drowsiness, or convulsions (seizures) may be more likely to occur in the elderly, who are usually more sensitive to the effects of this medicine. Also, increases in blood pressure may be more likely to occur in elderly persons taking decongestants.

Pregnancy

The occasional use of a cough/cold combination is not likely to cause problems in the fetus or in the newborn baby. However, when these medicines are used at higher doses and/or for a long time, the chance that problems might occur may increase. For the individual ingredients of these combinations, the following information should be considered before you decide to use a particular cough/cold combination:

Acetaminophen—Studies on birth defects have not been done in humans. However, acetaminophen has not been shown to cause birth defects or other problems in humans.
Alcohol—Some of these combination medicines contain a large amount of alcohol. Too much use of alcohol during pregnancy may cause birth defects.
Antihistamines—Antihistamines have not been shown to cause problems in humans.
Caffeine—Studies in humans have not shown that caffeine causes birth defects. However, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to the amount of caffeine contained in 12 to 24 cups of coffee a day).
Codeine—Although studies on birth defects with codeine have not been done in humans, it has not been reported to cause birth defects in humans. Codeine has not been shown to cause birth defects in animal studies, but it caused other unwanted effects. Also, regular use of narcotics during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. In addition, narcotics may cause breathing problems in the newborn baby if taken by the mother just before delivery.
Hydrocodone—Although studies on birth defects with hydrocodone have not been done in humans, it has not been reported to cause birth defects in humans. However, hydrocodone has been shown to cause birth defects in animals when given in very large doses. Also, regular use of narcotics during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. In addition, narcotics may cause breathing problems in the newborn baby if taken by the mother just before delivery.
Iodides (e.g., calcium iodide and iodinated glycerol)—Not recommended during pregnancy. Iodides have caused enlargement of the thyroid gland in the fetus and resulted in breathing problems in newborn babies whose mothers took iodides in large doses for a long period of time.
Phenylephrine—Studies on birth defects with phenylephrine have not been done in either humans or animals.
Pseudoephedrine—Studies on birth defects with pseudoephedrine have not been done in humans. In animal studies pseudoephedrine did not cause birth defects but did cause a decrease in average weight, length, and rate of bone formation in the animal fetus when given in high doses.
Salicylates (e.g., aspirin)—Studies on birth defects in humans have been done with aspirin, but not with salicylamide or sodium salicylate. Salicylates have not been shown to cause birth defects in humans. However, salicylates have been shown to cause birth defects in animals.

Some reports have suggested that too much use of aspirin late in pregnancy may cause a decrease in the newborn''s weight and possible death of the fetus or newborn infant. However, the mothers in these reports had been taking much larger amounts of aspirin than are usually recommended. Studies of mothers taking aspirin in the doses that are usually recommended did not show these unwanted effects. However, there is a chance that regular use of salicylates late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or newborn baby.

Use of salicylates, especially aspirin, during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery, or in the newborn baby. Also, too much use of salicylates during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery. Do not take aspirin during the last 3 months of pregnancy unless it has been ordered by your doctor.

Breastfeeding

If you are breastfeeding, the chance that problems might occur depends on the ingredients of the combination. For the individual ingredients of these combinations, the following apply:

Acetaminophen—Acetaminophen passes into the breast milk. However, it has not been reported to cause problems in nursing babies.
Alcohol—Alcohol passes into the breast milk. However, the amount of alcohol in recommended doses of this medicine does not usually cause problems in nursing babies.
Antihistamines—Small amounts of antihistamines pass into the breast milk. Antihistamine-containing medicine is not recommended for use while breastfeeding since most antihistamines are especially likely to cause side effects, such as unusual excitement or irritability, in the baby. Also, since antihistamines tend to decrease the secretions of the body, the flow of breast milk may be reduced in some patients.
Caffeine—Small amounts of caffeine pass into the breast milk and may build up in the nursing baby. However, the amount of caffeine in recommended doses of this medicine does not usually cause problems in nursing babies.
Codeine and other narcotic cough medicines (e.g., dihydrocodeine, hydrocodone, and hydromorphone)—Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the nursing baby and cause very serious side effects. A nursing mother should talk to her doctor if she has any questions about taking codeine or about how this medicine may affect her baby .
Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Phenylephrine has not been reported to cause problems in nursing babies. Ephedrine and pseudoephedrine pass into the breast milk and may cause unwanted effects in nursing babies (especially newborn and premature babies).
Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby.
Salicylates (e.g., aspirin)—Salicylates pass into the breast milk. Although salicylates have not been reported to cause problems in nursing babies, it is possible that problems may occur if large amounts are taken regularly.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Abrocitinib
Alfuzosin
Amiodarone
Amisulpride
Amitriptyline
Amprenavir
Anagrelide
Apomorphine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Artemether
Asenapine
Astemizole
Atazanavir
Azithromycin
Bedaquiline
Bepridil
Boceprevir
Buprenorphine
Buserelin
Cabotegravir
Calcium Oxybate
Ceritinib
Chloroquine
Chlorpromazine
Ciprofloxacin
Cisapride
Citalopram
Clarithromycin
Clofazimine
Clomipramine
Clorgyline
Clothiapine
Clozapine
Cobicistat
Crizotinib
Cyclobenzaprine
Dabrafenib
Darunavir
Dasabuvir
Dasatinib
Defibrotide
Degarelix
Delamanid
Delavirdine
Desipramine
Deslorelin
Deutetrabenazine
Dexmedetomidine
Dichlorphenamide
Dihydroergotamine
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doravirine
Doxepin
Dronedarone
Droperidol
Ebastine
Efavirenz
Elvitegravir
Encorafenib
Entrectinib
Eribulin
Erythromycin
Escitalopram
Famotidine
Felbamate
Fexinidazole
Fingolimod
Flecainide
Fluoxetine
Fluvoxamine
Formoterol
Foscarnet
Fosphenytoin
Fostemsavir
Furazolidone
Galantamine
Gatifloxacin
Gemifloxacin
Glasdegib
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Histrelin
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Iloperidone
Imipramine
Indinavir
Influenza Virus Vaccine, Live
Inotuzumab Ozogamicin
Iproniazid
Isocarboxazid
Itraconazole
Ivabradine
Ivosidenib
Ketoconazole
Ketorolac
Lapatinib
Lenvatinib
Leuprolide
Levofloxacin
Levoketoconazole
Levomethadyl
Linezolid
Lofexidine
Lumefantrine
Macimorelin
Magnesium Oxybate
Maraviroc
Mavacamten
Mefloquine
Mesoridazine
Methadone
Methotrimeprazine
Methylene Blue
Metronidazole
Mifepristone
Mirtazapine
Mizolastine
Mobocertinib
Moclobemide
Moricizine
Moxifloxacin
Nafarelin
Nalmefene
Naltrexone
Nefazodone
Nelfinavir
Nialamide
Nilotinib
Nirmatrelvir
Norfloxacin
Octreotide
Ofloxacin
Olanzapine
Ombitasvir
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Ozanimod
Pacritinib
Paliperidone
Panobinostat
Papaverine
Pargyline
Paritaprevir
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Perphenazine
Phenelzine
Pimavanserin
Pimozide
Pipamperone
Piperaquine
Pitolisant
Ponesimod
Posaconazole
Potassium Citrate
Potassium Oxybate
Praziquantel
Probucol
Procainamide
Procarbazine
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Rasagiline
Ribociclib
Rilpivirine
Riociguat
Risperidone
Ritonavir
Safinamide
Samidorphan
Saquinavir
Selegiline
Selpercatinib
Sertindole
Sertraline
Sevoflurane
Sibutramine
Sodium Oxybate
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Sparfloxacin
Sulpiride
Sultopride
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Telavancin
Telithromycin
Tenofovir Alafenamide
Tetrabenazine
Thioridazine
Tipranavir
Toloxatone
Tolterodine
Toremifene
Tranylcypromine
Trazodone
Triclabendazole
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilanterol
Viloxazine
Vinflunine
Voclosporin
Voriconazole
Vorinostat
Ziprasidone
Zolmitriptan
Zotepine

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Abciximab
Acarbose
Aceclofenac
Acemetacin
Acenocoumarol
Acepromazine
Acetazolamide
Acetyldigoxin
Adagrasib
Adenosine
Alefacept
Alfentanil
Alipogene Tiparvovec
Almotriptan
Alprazolam
Alteplase, Recombinant
Amifampridine
Amiloride
Amineptine
Amiodarone
Amitriptyline
Amitriptylinoxide
Amobarbital
Amoxapine
Amphetamine
Amprenavir
Amtolmetin Guacil
Amygdalin
Anagrelide
Ancrod
Anileridine
Anisindione
Antithrombin III Human
Apixaban
Aprepitant
Aprobarbital
Ardeparin
Argatroban
Aripiprazole
Armodafinil
Arsenic Trioxide
Asenapine
Aspirin
Atazanavir
Atogepant
Avacopan
Avapritinib
Axitinib
Baclofen
Balsalazide
Bemiparin
Bendroflumethiazide
Benperidol
Benzhydrocodone
Benzphetamine
Benzthiazide
Betamethasone
Betrixaban
Bisacodyl
Bismuth Subsalicylate
Bivalirudin
Boceprevir
Bosentan
Brigatinib
Bromazepam
Bromfenac
Bromocriptine
Bromopride
Bromperidol
Brompheniramine
Bucindolol
Budesonide
Bufexamac
Bumetanide
Bupivacaine
Buprenorphine
Bupropion
Buspirone
Butabarbital
Butalbital
Butorphanol
Calcifediol
Calcium Oxybate
Cangrelor
Cannabidiol
Caplacizumab-yhdp
Capmatinib
Carbamazepine
Carbinoxamine
Carisoprodol
Carmustine
Carphenazine
Carteolol
Carvedilol
Celecoxib
Ceritinib
Certoparin
Cetirizine
Chloral Hydrate
Chlordiazepoxide
Chlorothiazide
Chlorpheniramine
Chlorpromazine
Chlorpropamide
Chlortetracycline
Chlorthalidone
Chlorzoxazone
Choline Magnesium Trisalicylate
Choline Salicylate
Cilostazol
Cimetidine
Cinacalcet
Ciprofloxacin
Citalopram
Clarithromycin
Clobazam
Clomipramine
Clonazepam
Clonixin
Clopamide
Clopidogrel
Clorazepate
Clozapine
Cobicistat
Cobimetinib
Cocaine
Codeine
Conivaptan
Cortisone
Crizotinib
Cyclobenzaprine
Cyclopenthiazide
Cyclosporine
Dabigatran Etexilate
Daclatasvir
Dalteparin
Danaparoid
Dantrolene
Daridorexant
Darunavir
Dasabuvir
Deferasirox
Deferoxamine
Defibrotide
Deflazacort
Delafloxacin
Delavirdine
Demeclocycline
Dermatan Sulfate
Desipramine
Desirudin
Deslanoside
Desmopressin
Desogestrel
Desvenlafaxine
Dexamethasone
Dexibuprofen
Dexketoprofen
Dexmedetomidine
Dextroamphetamine
Dextromethorphan
Dezocine
Diacetylmorphine
Diazepam
Diazoxide
Dibenzepin
Dichloralphenazone
Diclofenac
Dicumarol
Dienogest
Difenoxin
Diflunisal
Digitalis
Digitoxin
Digoxin
Dihydroartemisinin
Dihydrocodeine
Dilevalol
Diltiazem
Dinoprostone
Diphenhydramine
Diphenoxylate
Dipyridamole
Dipyrone
Dixyrazine
Dolasetron
Dolutegravir
Domperidone
Donepezil
Dothiepin
Doxepin
Doxorubicin
Doxorubicin Hydrochloride Liposome
Doxycycline
Doxylamine
Dronedarone
Droperidol
Drospirenone
Droxicam
Duloxetine
Duvelisib
Edoxaban
Efavirenz
Elbasvir
Eletriptan
Encorafenib
Enflurane
Enoxacin
Enoxaparin
Entacapone
Entrectinib
Enzalutamide
Epinephrine
Eplerenone
Epoprostenol
Eptifibatide
Eravacycline
Erdafitinib
Ergonovine
Erlotinib
Erythromycin
Escitalopram
Esketamine
Eslicarbazepine Acetate
Estazolam
Estradiol
Eszopiclone
Ethacrynic Acid
Ethchlorvynol
Ethinyl Estradiol
Ethopropazine
Ethylmorphine
Ethynodiol
Etintidine
Etodolac
Etofenamate
Etonogestrel
Etoricoxib
Etravirine
Fedratinib
Felbinac
Fenfluramine
Fenoprofen
Fentanyl
Fepradinol
Feprazone
Feverfew
Fexinidazole
Fexofenadine
Finerenone
Flibanserin
Floctafenine
Fluconazole
Flufenamic Acid
Flunitrazepam
Fluocortolone
Fluoxetine
Fluphenazine
Flurazepam
Flurbiprofen
Fluspirilene
Fluvoxamine
Fondaparinux
Fosamprenavir
Fosaprepitant
Fosnetupitant
Fosphenytoin
Fospropofol
Frovatriptan
Furazolidone
Furosemide
Gabapentin
Gabapentin Enacarbil
Gatifloxacin
Gemifloxacin
Gestodene
Ginkgo
Givosiran
Glasdegib
Glimepiride
Glipizide
Glucagon
Glyburide
Glycopyrrolate
Glycopyrronium Tosylate
Gossypol
Granisetron
Grazoprevir
Grepafloxacin
Guanethidine
Halazepam
Haloperidol
Halothane
Hemin
Heparin
Hexobarbital
Hyaluronidase
Hydrochlorothiazide
Hydrocodone
Hydrocortisone
Hydroflumethiazide
Hydromorphone
Hydroxytryptophan
Hydroxyzine
Ibrexafungerp
Ibrutinib
Ibuprofen
Idelalisib
Idrocilamide
Ifosfamide
Iloprost
Imatinib
Imipenem
Imipramine
Indapamide
Indinavir
Indomethacin
Infigratinib
Inotersen
Iobenguane I 123
Iobenguane I 131
Iproniazid
Iron
Isocarboxazid
Isoflurane
Isoniazid
Itraconazole
Ivacaftor
Ketamine
Ketazolam
Ketobemidone
Ketoconazole
Ketoprofen
Lamotrigine
Larotrectinib
Lasmiditan
Ledipasvir
Lefamulin
Lemborexant
Lenacapavir
Lepirudin
Levalbuterol
Levobunolol
Levocetirizine
Levofloxacin
Levoleucovorin
Levomilnacipran
Levonorgestrel
Levorphanol
Licorice
Linezolid
Lisdexamfetamine
Lithium
Lofepramine
Lofexidine
Lomefloxacin
Lomitapide
Lopinavir
Lorazepam
Lorcaserin
Lorlatinib
Lormetazepam
Lornoxicam
Loxapine
Loxoprofen
Lumacaftor
Lumateperone
Lumiracoxib
Lurbinectedin
Lymecycline
Macimorelin
Magnesium Oxybate
Magnesium Salicylate
Maribavir
Meadowsweet
Meclizine
Meclocycline
Meclofenamate
Medazepam
Medroxyprogesterone
Mefenamic Acid
Melitracen
Meloxicam
Melperone
Memantine
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Meptazinol
Mesalamine
Mesoridazine
Mestranol
Metaxalone
Metformin
Methacholine
Methacycline
Methadone
Methamphetamine
Methdilazine
Methocarbamol
Methohexital
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Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol
Grapefruit Juice
Tobacco

Proper use of Zyrtec-D

This section provides information on the proper use of a number of products that contain cough and cold combinations. It may not be specific to Zyrtec-D. Please read with care.

To help loosen mucus or phlegm in the lungs, drink a glass of water after each dose of this medicine, unless otherwise directed by your doctor.

Take this medicine only as directed. Do not take more of it and do not take it more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.

For patients taking the extended-release capsule or tablet form of this medicine:

Swallow the capsule or tablet whole.
Do not crush, break, or chew before swallowing.
If the capsule is too large to swallow, you may mix the contents of the capsule with applesauce, jelly, honey, or syrup and swallow without chewing.

For patients taking the extended-release oral solution or oral suspension form of this medicine:

Do not dilute with fluids or mix with other drugs.

For patients taking a combination medicine containing an antihistamine and/or aspirin or other salicylate:

Take with food or a glass of water or milk to lessen stomach irritation, if necessary.

If a combination medicine containing aspirin has a strong vinegar-like odor, do not use it. This odor means the medicine is breaking down. If you have any questions about this, check with your pharmacist.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Keep the liquid form of this medicine from freezing. Do not refrigerate the syrup.

Precautions while using Zyrtec-D

If your cough has not improved after 7 days or if you have a high fever, skin rash, continuing headache, or sore throat with the cough, check with your doctor. These signs may mean that you have other medical problems.

For patients taking a codeine-containing medicine or any other narcotic analgesics (e.g., dihydrocodeine, hydrocodone, oxycodone, and pentazocine):

Contact your doctor immediately if you experience extreme sleepiness, confusion, or shallow breathing. These symptoms may indicate that you are an "ultra-rapid metabolizer of codeine". Ultra-rapid metabolizers change codeine to morphine more quickly and completely than other people. As a result, there is too much morphine in the body and more side effects of morphine than usual

For nursing mothers taking a codeine-containing medicine or any other narcotic cough medicine (dihydrocodeine, hydrocodone, or hydromorphone):

Call your doctor if you become extremely tired and have difficulty caring for your baby.
Your baby should generally nurse every two to three hours and should not sleep more than four hours at a time.
Check with your doctor or hospital emergency room immediately if your baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, difficulty breathing, or limpness. These may be symptoms of an overdose and need immediate medical attention .

For patients taking antihistamine-containing medicine:

Before you have any skin tests for allergies, tell the doctor in charge that you are taking this medicine. The results of the test may be affected by the antihistamine in this medicine.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.
This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally.
Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
When taking antihistamines on a regular basis, make sure your doctor knows if you are taking large amounts of aspirin at the same time (as in arthritis or rheumatism). Effects of too much aspirin, such as ringing in the ears, may be covered up by the antihistamine.
Antihistamines may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

For patients taking decongestant-containing medicine:

This medicine may add to the central nervous system (CNS) stimulant effects of diet aids. Do not use medicines for diet or appetite control while taking this medicine unless you have checked with your doctor.
This medicine may cause some people to be nervous or restless or to have trouble in sleeping. If you have trouble in sleeping, take the last dose of this medicine for each day a few hours before bedtime. If you have any questions about this, check with your doctor.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

For patients taking narcotic antitussive (codeine, dihydrocodeine, hydrocodone, or hydromorphone)-containing medicine:

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.
This medicine may cause some people to become drowsy, dizzy, less alert than they are normally, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded.
Nausea or vomiting may occur after taking a narcotic antitussive. This effect may go away if you lie down for a while. However, if nausea or vomiting continues, check with your doctor.
Dizziness, lightheadedness, or fainting may be especially likely to occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

For patients taking iodide (calcium iodide, iodinated glycerol, or potassium iodide)-containing medicine:

Make sure your doctor knows if you are planning to have any future thyroid tests. The results of the thyroid test may be affected by the iodine in this medicine.

For patients taking analgesic-containing medicine:

Check the label of all nonprescription (over-the-counter [OTC]), and prescription medicines you now take. If any contain acetaminophen or aspirin or other salicylates, including diflunisal or bismuth subsalicylate, be especially careful. Taking them while taking a cough/cold combination medicine that already contains them may lead to overdose. If you have any questions about this, check with your health care professional.
Do not take aspirin-containing medicine for 5 days before any surgery, including dental surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.

For diabetic patients taking aspirin- or sodium salicylate-containing medicine:

False urine sugar test results may occur:
- If you take 8 or more 325-mg doses of aspirin every day for several days in a row.
- If you take 8 or more 325-mg or 4 or more 500-mg doses of sodium salicylate.
Smaller doses or occasional use of aspirin or sodium salicylate usually will not affect urine sugar tests. If you have any questions about this, check with your health care professional, especially if your diabetes is not well controlled.

For patients taking homatropine-containing medicine:

This medicine may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint while you are taking this medicine.

Zyrtec-D side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Although serious side effects occur rarely when this medicine is taken as recommended, they may be more likely to occur if: too much medicine is taken, it is taken in large doses, or it is taken for a long period of time.

Get emergency help immediately if any of the following symptoms of overdose occur:

For narcotic antitussive (codeine, dihydrocodeine, hydrocodone, or hydromorphone)-containing

If you are a nursing mother and you notice any of the following symptoms of overdose in your baby, get emergency help immediately:

Cold, clammy skin
confusion (severe)
convulsions (seizures)
drowsiness or dizziness (severe)
nervousness or restlessness (severe)
pinpoint pupils of eyes
slow heartbeat
slow or troubled breathing
Difficulty breathing
difficulty nursing
increased sleepiness (more than usual)
limpness

For acetaminophen-containing

Diarrhea
increased sweating
loss of appetite
nausea or vomiting
stomach cramps or pain
swelling or tenderness in the upper abdomen or stomach area

For salicylate-containing

Any loss of hearing
bloody urine
confusion
convulsions (seizures)
dizziness or lightheadedness
drowsiness (severe)
excitement or nervousness (severe)
fast or deep breathing
fever
hallucinations (seeing, hearing, or feeling things that are not there)
increased sweating
nausea or vomiting (severe or continuing)
shortness of breath or troubled breathing (for salicylamide only)
stomach pain (severe or continuing)
uncontrollable flapping movements of the hands, especially in elderly patients
unusual thirst
vision problems

For decongestant-containing

Fast, pounding, or irregular heartbeat
headache (continuing and severe)
nausea or vomiting (severe)
nervousness or restlessness (severe)
shortness of breath or troubled breathing (severe or continuing)

Check with your doctor as soon as possible if any of the following side effects occur:

For all combinations

Skin rash, hives, and/or itching

For antihistamine- or anticholinergic-containing

Clumsiness or unsteadiness
convulsions (seizures
drowsiness (severe)
dryness of mouth, nose, or throat (severe)
flushing or redness of face
hallucinations (seeing, hearing, or feeling things that are not there)
restlessness (severe)
shortness of breath or troubled breathing
slow or fast heartbeat

For iodine-containing

Headache (continuing)
increased watering of mouth
loss of appetite
metallic taste
skin rash, hives, or redness
sore throat
swelling of face, lips, or eyelids

For acetaminophen-containing

Unexplained sore throat and fever
unusual tiredness or weakness
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Constipation
decreased sweating
difficult or painful urination
dizziness or lightheadedness
drowsiness
dryness of mouth, nose, or throat
false sense of well-being
increased sensitivity of skin to sun
nausea or vomiting
nightmares
stomach pain
thickening of mucus
trouble in sleeping
unusual excitement, nervousness, restlessness, or irritability
unusual tiredness or weakness

Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. There are some similarities among these combination medicines, so many of the above side effects may occur with any of these medicines.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drug name: Zyrtec-D (Oral)