Adagrasib (Oral)

Medically reviewed by Drugs.com. Last updated on Aug 2, 2022.

Commonly used brand name(s)

In the U.S.

• Krazati

Available Dosage Forms:

• Tablet

Therapeutic Class: Antineoplastic Agent

Uses for adagrasib

Adagrasib is used to treat metastatic (cancer that has already spread) or locally advanced (cannot be removed by surgery) non-small cell lung cancer (NSCLC) in patients who have received at least one previous treatment and whose tumors have an abnormal KRAS G12C gene. Your doctor will perform a test before you use adagrasib.

Adagrasib belongs to the group of medicines called antineoplastics (cancer medicines). It works by interfering with the growth of cancer cells, which are eventually destroyed.

Adagrasib is available only with your doctor''s prescription.

Before using adagrasib

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For adagrasib, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to adagrasib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of adagrasib in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of adagrasib in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking adagrasib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using adagrasib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acalabrutinib
• Afatinib
• Alfentanil
• Alfuzosin
• Aliskiren
• Amiodarone
• Amisulpride
• Amitriptyline
• Anagrelide
• Apalutamide
• Apixaban
• Apomorphine
• Aprepitant
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Atomoxetine
• Avanafil
• Avapritinib
• Azithromycin
• Bedaquiline
• Bepridil
• Betrixaban
• Boceprevir
• Bosutinib
• Budesonide
• Buprenorphine
• Buserelin
• Buspirone
• Carbamazepine
• Celecoxib
• Ceritinib
• Chloroquine
• Chlorpromazine
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clozapine
• Cobicistat
• Cobimetinib
• Colchicine
• Conivaptan
• Crizotinib
• Cyclobenzaprine
• Cyclosporine
• Dabigatran Etexilate
• Dabrafenib
• Darifenacin
• Darolutamide
• Darunavir
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dextromethorphan
• Digoxin
• Dihydroergotamine
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Dronedarone
• Droperidol
• Ebastine
• Edoxaban
• Efavirenz
• Elagolix
• Eletriptan
• Eliglustat
• Encorafenib
• Entrectinib
• Enzalutamide
• Eplerenone
• Ergotamine
• Eribulin
• Erythromycin
• Escitalopram
• Everolimus
• Famotidine
• Felbamate
• Felodipine
• Fentanyl
• Fexinidazole
• Fexofenadine
• Finerenone
• Fingolimod
• Flecainide
• Flibanserin
• Fluconazole
• Fluoxetine
• Fluticasone
• Formoterol
• Fosaprepitant
• Foscarnet
• Fosphenytoin
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gilteritinib
• Glasdegib
• Glecaprevir
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibrexafungerp
• Ibrutinib
• Ibutilide
• Idelalisib
• Iloperidone
• Imipramine
• Indinavir
• Inotuzumab Ozogamicin
• Itraconazole
• Ivabradine
• Ivacaftor
• Ivosidenib
• Ketoconazole
• Lapatinib
• Ledipasvir
• Lefamulin
• Lenvatinib
• Leuprolide
• Levofloxacin
• Lofexidine
• Lomitapide
• Loperamide
• Lopinavir
• Lovastatin
• Lumacaftor
• Lumefantrine
• Lurasidone
• Macimorelin
• Maraviroc
• Mefloquine
• Mesoridazine
• Methadone
• Methotrimeprazine
• Metoprolol
• Metronidazole
• Midazolam
• Mifepristone
• Mitotane
• Mizolastine
• Mobocertinib
• Moricizine
• Moxifloxacin
• Nafarelin
• Naldemedine
• Naloxegol
• Nebivolol
• Nefazodone
• Nelfinavir
• Nilotinib
• Nintedanib
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Paliperidone
• Panobinostat
• Papaverine
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Perphenazine
• Phenytoin
• Pibrentasvir
• Pimavanserin
• Pimozide
• Pipamperone
• Piperaquine
• Pitolisant
• Ponesimod
• Posaconazole
• Probucol
• Procainamide
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Relugolix
• Ribociclib
• Rifampin
• Rimegepant
• Risperidone
• Ritonavir
• Rivaroxaban
• Saquinavir
• Selpercatinib
• Sertindole
• Sertraline
• Sevoflurane
• Sildenafil
• Simvastatin
• Siponimod
• Sirolimus
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Sofosbuvir
• Solifenacin
• Sorafenib
• Sotalol
• Sparfloxacin
• St John''s Wort
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Talazoparib
• Tamoxifen
• Telaprevir
• Telavancin
• Telithromycin
• Temsirolimus
• Tenofovir Alafenamide
• Terfenadine
• Tetrabenazine
• Thioridazine
• Ticagrelor
• Tipranavir
• Tizanidine
• Tolterodine
• Tolvaptan
• Topotecan
• Toremifene
• Trazodone
• Triazolam
• Triclabendazole
• Trimipramine
• Triptorelin
• Ubrogepant
• Vandetanib
• Vardenafil
• Velpatasvir
• Vemurafenib
• Venetoclax
• Venlafaxine
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Vorinostat
• Voxilaprevir
• Warfarin
• Ziprasidone
• Zotepine
• Zuclopenthixol

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of adagrasib. Make sure you tell your doctor if you have any other medical problems, especially:

• Heart failure or
• Heart rhythm problems or
• Liver disease or
• Lung or breathing problems (eg, interstitial lung disease, pneumonitis)—Use with caution. May make these conditions worse.

Proper use of adagrasib

Medicines used to treat cancer are very strong and can have many side effects. Before receiving adagrasib, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take adagrasib exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

You may take adagrasib with or without food. Take the medicine at the same time each day.

Swallow the tablet whole. Do not chew, crush, or split it.

Dosing

The dose of adagrasib will be different for different patients. Follow your doctor''s orders or the directions on the label. The following information includes only the average doses of adagrasib. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  • For non-small cell lung cancer:
    • Adults—600 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed and tolerated.
    • Children—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of adagrasib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If a dose is missed by more than 4 hours or if you vomit after you take a dose, do not take an extra dose. Take the next dose at the regular scheduled time. Do not take extra medicine to make up for the missed dose.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using adagrasib

It is very important that your doctor check your progress at regular visits to make sure adagrasib is working properly. Blood tests may be needed to check for unwanted effects.

Adagrasib may cause diarrhea, nausea, vomiting, or serious stomach and bowel problems (eg, bleeding, blockage, swelling, narrowing), Check with your doctor right away if you have fever, pain, stomach pain, cramps, or tenderness, watery or bloody diarrhea. Your doctor may give you medicines (eg, diarrhea medicine) to treat it.

Adagrasib may increase risk of heart rhythm problems, including QT prolongation and torsade de pointes. Check with your doctor right away if you have chest pain or discomfort, irregular or slow heart rate, fainting, or trouble breathing.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Adagrasib may cause swelling of the lungs (pneumonitis) or interstitial lung disease. These are life-threatening conditions and require immediate medical attention. The symptoms may be similar to the symptoms from lung cancer. Check with your doctor right away if you have new or worsening cough, fever, or trouble breathing.

Talk with your doctor before using adagrasib if you plan to have children. Some men and women using adagrasib have become infertile (unable to have children).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Adagrasib side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Agitation
• bloody urine
• bone pain
• chest pain, discomfort, or tightness
• coma
• confusion
• constipation
• cough
• dark urine
• decreased amount of urine
• depression
• diarrhea
• dizziness
• fainting
• fast heartbeat
• fever or chills
• headache
• hostility
• increased blood pressure
• increased thirst
• irregular or slow heart rate
• irritability
• lethargy
• lightheadedness
• loss of appetite
• lower back or side pain
• muscle twitching
• nausea
• rapid, shallow breathing
• seizures
• sneezing
• sore throat
• stomach pain, severe
• stupor
• swelling
• swelling of the face, fingers, or lower legs
• trouble breathing
• unusual tiredness or weakness
• vomiting
• weight gain
• yellow eyes or skin

Less common

• Anxiety
• blue lips, fingernails, or skin
• blurred vision
• coughing up blood
• decreased appetite
• decreased urination
• decreased weight
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• muscle pain or cramps
• nightmares or unusually vivid dreams
• pale skin
• sunken eyes
• sweating
• unusual bleeding or bruising
• wrinkled skin

Rare

• Inability to speak
• slurred speech
• stiffness
• temporary blindness
• weakness in the arm or legs on one side of the body, sudden and severe

Incidence not known

• General feeling of discomfort or illness
• thickening of bronchial secretions

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer