Description:

Vivelle 100 Mcg (Transdermal)

Generic name: estradiol (transdermal route) [ es-tra-DYE-ol ]
Drug class: Estrogens

Medically reviewed by Drugs.com. Last updated on Oct 10, 2022.

Transdermal route(Gel/Jelly)

For estrogen-alone therapy. there is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia. The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT). WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older. Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE), and myocardial infarction. The WHI estrogen plus progestin study reported increased risks of invasive breast cancer. The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older .

Transdermal route(Patch, Extended Release;Gel/Jelly)

Estrogen Alone TherapyEndometrial Cancer - There is an increased risk of cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding Cardiovascular Disorders and Probable Dementia - Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia .Cardiovascular Disorders and Probable Dementia - The Women''s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg]-alone, relative to placebo .Cardiovascular Disorders and Probable Dementia - The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg)-alone, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women .Cardiovascular Disorders and Probable Dementia - In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and other dosage forms of estrogens .Cardiovascular Disorders and Probable Dementia - Only daily oral 0.625 mg CE was studied in the estrogen -alone substudy of the WHI. Therefore, thee relevance of the WHI findings regarding adverse cardiovascular events and dementia to lower CE doses, other routes of administration, or other estrogen-alone products is not known. Without such data, it is not possible to definitively exclude these risks or determine the extent of these risks for other products. Discuss with your patient the benefits and risks of estrogen-alone therapy, taking into account her individual risk profile .Cardiovascular Disorders and Probable Dementia - Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman .Estrogen Plus Progestin TherapyCardiovascular Disorders and Probable Dementia - Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia .Cardiovascular Disorders and Probable Dementia - The WHI estrogen plus progestin substudy reported increased risks of DVT, pulmonary embolism (PE), stroke and myocardial infarction (MI) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral CE (0.625 mg) combined with combined medroxyprogesterone acetate (MPA) [2.5 mg], relative to placebo .Cardiovascular Disorders and Probable Dementia - The WHIMS estrogen plus progestin ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age and older during 4 years of treatment with daily CE (0.625 mg) combined with MPA (2.5 mg), relative to placebo. It is unknown whether this finding applies to younger postmenopausal women .Breast Cancer - The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer .Breast Cancer - In the absence of comparable data, these risks should be assumed to be similar for other doses of CE and MPA, and other combinations and dosage forms of estrogens and progestins .Breast Cancer - Only daily oral 0.625 mg CE and 2.5 mg MPA were studied in the estrogen plus progestin substudy of the WHI. Therefore, the relevance of the WHI findings regarding adverse cardiovascular events, dementia, and breast cancer to lower CE plus other MPA doses, other routes of administration, or other estrogen plus progestogen products is not known. Without such data, it is not possible to definitively exclude these risks or determine the extent of these risks for other products. Discuss with your patient the benefits and risks of estrogen plus progestogen therapy, taking into account her individual risk profile .Breast Cancer - Estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman .

Transdermal route(Spray)

Estrogen Alone TherapyThere is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia. The Women''s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT). The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported increased risk of probable dementia in postmenopausal women 65 years or older.Estrogen Plus Progestin TherapyEstrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE), and myocardial infarction (MI). The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer. The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older.Unintentional Secondary ExposureBreast budding, breast masses, and gynecomastia have been reported in children following unintentional secondary exposure to estradiol transdermal spray .

Commonly used brand name(s)

In the U.S.

Alora
Climara
Divigel
Elestrin
Esclim
Estraderm
Estrasorb
EstroGel
Evamist
Menostar
Minivelle
Vivelle
Vivelle-Dot

In Canada

Estradot Transdermal
Estradot Transdermal Therapeutic System
Estradot Transdermal Therapeutic System
Oesclim
Rhoxal-Estradiol Derm 50
Rhoxal-Estradiol Derm 75
Roxal-Estradiol Derm 100
Vivelle 100 Mcg
Vivelle 25 Mcg
Vivelle 37.5 Mcg

Available Dosage Forms:

Patch, Extended Release
Gel/Jelly
Spray

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Estrogen

Related/similar drugs

alendronate, finasteride, estradiol, tamoxifen, Fosamax, Premarin, testosterone

Uses for Vivelle 100 Mcg

Estradiol transdermal gel, patch, and spray are used to treat moderate to severe symptoms of menopause (eg, feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating [hot flashes]) in women with a uterus. It is also used to treat changes in and around the vagina (eg, vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. This medicine is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogens naturally, and prevent osteoporosis after menopause.

Estradiol is an estrogen hormone. The hormone from the patch, gel, and spray is absorbed through your skin into your body.

This medicine is available only with your doctor''s prescription.

Before using Vivelle 100 Mcg

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of estradiol transdermal patch, gel, and spray is not indicated in the pediatric population. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of estradiol transdermal patch, gel, and spray have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have breast cancer, stroke, or dementia, which may require caution in patients receiving estradiol transdermal patch, gel and spray.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Tranexamic Acid

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Amifampridine
Amoxicillin
Ampicillin
Amprenavir
Apalutamide
Aprepitant
Armodafinil
Artemether
Bacampicillin
Belzutifan
Betamethasone
Bexarotene
Bosentan
Bupropion
Carbamazepine
Carbenicillin
Cefaclor
Cefadroxil
Cefdinir
Cefditoren
Cefixime
Cefpodoxime
Cefprozil
Ceftazidime
Ceftibuten
Cefuroxime
Cenobamate
Ceritinib
Clavulanic Acid
Clobazam
Cloxacillin
Colesevelam
Conivaptan
Cyclacillin
Cyclosporine
Dabrafenib
Darunavir
Dexamethasone
Dicloxacillin
Donepezil
Doxycycline
Efavirenz
Elagolix
Elvitegravir
Encorafenib
Enzalutamide
Eslicarbazepine Acetate
Etravirine
Fedratinib
Fexinidazole
Fosamprenavir
Fosaprepitant
Fosnetupitant
Fosphenytoin
Griseofulvin
Guar Gum
Isotretinoin
Ivosidenib
Lesinurad
Lixisenatide
Lorlatinib
Lumacaftor
Mavacamten
Minocycline
Mitapivat
Mitotane
Mobocertinib
Modafinil
Mycophenolate Mofetil
Mycophenolic Acid
Nafcillin
Nelfinavir
Netupitant
Nevirapine
Octreotide
Oxacillin
Oxcarbazepine
Oxytetracycline
Penicillin G
Penicillin G Procaine
Penicillin V
Phenobarbital
Phenylbutazone
Phenytoin
Pitolisant
Pixantrone
Prednisone
Primidone
Rifabutin
Rifampin
Rifapentine
Ritonavir
Rufinamide
Secobarbital
St John''s Wort
Sugammadex
Sultamicillin
Tazemetostat
Telaprevir
Tetracycline
Theophylline
Ticarcillin
Tigecycline
Tirzepatide
Tizanidine
Topiramate
Ulipristal
Valproic Acid

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Atazanavir
Diazepam
Ginseng
Lamotrigine
Levothyroxine
Licorice
Lorazepam
Prednisolone
Selegiline
Tacrine
Temazepam
Tipranavir
Triazolam
Troleandomycin
Voriconazole
Warfarin

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Caffeine

Proper use of Vivelle 100 Mcg

This section provides information on the proper use of a number of products that contain estradiol. It may not be specific to Vivelle 100 Mcg. Please read with care.

It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.

This medicine is for use on the skin only. Do not get it in your eyes, nose, mouth, breast, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Wash your hands with soap and water before and after using this medicine.

To use the patch:

Wash your hands with soap and water before and after you use this medicine.
Carefully tear open the pouch when you are ready to put the patch on your skin. Do not cut it.
Peel off the backing from the patch and apply the patch to a clean, dry, and hair-free area of the lower stomach or upper buttock area. This area must be free of powder, oil, or lotion for the patch to stick on to your skin.
Press the patch firmly in place with your hand for about 10 seconds.
Do not apply the patch on the breast or over any skin folds. Do not apply the patch on oily, broken, burned, or irritated skin, or areas with skin conditions (eg, birth marks, tattoos). Avoid applying the patch on the waistline or other places where tight clothing may rub it off.
Wear the patch at all times until it is time to put on a new patch. Do not expose it to the sun for long periods of time.
When replacing your patch, make sure to apply the new patch to a different area of your lower abdomen. Wait at least 1 week before applying a patch to the same area.
When changing a patch, slowly peel it off from your skin. If you have any patch adhesive left on your skin, allow it to dry for 15 minutes and gently rub the sticky area with oil or lotion to remove it. It is best to change your patch on the same days of each week to help you remember.
You may take a bath, shower, or swim while using this medicine. Doing so will not affect the patch.
If a patch falls off, just put it back on a different area. If the patch does not stick completely, put on a new patch but continue to follow your original schedule for changing your patch.
To throw away a used patch: Fold the patch in half with the sticky side together and place it in a sturdy child-proof container. Throw this container in the trash away from children and pets. Do not flush the patch down the toilet.

To use the spray:

The spray form of this medicine comes in an applicator that delivers a measured amount of estradiol to the skin with each spray. When using a new spray applicator, prime the pump by holding the spray upright and pumping 3 times. Priming is only necessary the first time you use a new spray applicator. Do not prime again.
Apply the medicine to clean, dry, and unbroken skin on the inside of the forearm between the elbow and the wrist. Do not apply the medicine directly to your breasts or in or around the vagina.
Allow the medicine to dry for at least 2 minutes before dressing, and at least 1 hour before washing.
If your doctor tells you to increase your dose, move the applicator to an area of the skin next to your previous application site, before applying the second or third spray.
Do not rub Evamist® spray into your skin.
Do not allow your child to touch the area of the arm where the medicine was sprayed. If you cannot avoid being close with your child, wear clothes with long sleeves to cover the application site.
If your child comes in direct contact with the arm where the medicine was sprayed, wash your child''s skin right away with soap and water.
Do not allow your pets to lick or touch the arm where the medicine was sprayed.
Always place the protective cover back on the applicator of the spray.
Do not use the applicator for more than 75 sprays.
Apply sunscreen at least 1 hour before applying Evamist®.

To use the gel:

The gel form of this medicine comes in a pump. Each time you press the pump you will get the same amount of medication. You may need to prime the pump by pumping 3 times (EstroGel®) or 10 times (Elestrin™) the first time you use it. Follow the patient instructions for the container you use. After you prime the pump, do not press the pump more than 1 time each time you use it.
Apply the gel to clean, dry, and unbroken skin. Spread the gel as thinly as possible over the entire area on the inside and outside of your upper arm and shoulder area. Do not apply the medicine directly to your breasts or in or around your vagina.
Do not allow others to come in contact with the area of skin where you applied the gel for at least 1 hour after you use the medicine. Do not allow others to apply the gel for you. Allow the medicine to dry for at least 5 minutes before you dress.
Apply sunscreen at least 25 minutes after using the gel. Avoid applying sunscreen on the same application site for 7 days or more.

The gel and spray contain alcohol and are flammable. Avoid using it near an open flame or while smoking.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor''s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For hot flashes and other symptoms caused by menopause:
- For transdermal dosage form (gel):
  - Adults—
    - Elestrin™: Apply one dose (0.87 grams) of the gel to the upper arm once a day. Your doctor may adjust your dose as needed.
    - EstroGel®: Apply one dose (1.25 grams) of the gel to the arm once a day. Your doctor may adjust your dose as needed.
  - Children—Use is not recommended.
- For transdermal dosage form (patch):
  - Adults—
    - Climara®: At first, apply one patch (0.025 milligrams (mg)) to the lower stomach or upper buttocks area once a week. Your doctor may adjust your dose as needed.
    - Minivelle® and Vivelle-Dot®: At first, apply one patch (0.0375 milligrams (mg)) to the lower stomach or upper buttocks area 2 times a week (every 3 to 4 days). Your doctor may adjust your dose as needed.
  - Children—Use is not recommended.
- For transdermal dosage form (spray):
  - Adults—At first, one spray once a day, usually in the morning. Your doctor may adjust your dose as needed.
  - Children—Use is not recommended.
For prevention of osteoporosis after menopause:
- For transdermal dosage form (patch):
  - Adults—
    - Climara®: At first, apply one patch (0.025 milligrams (mg)) to the lower stomach or upper buttock area once a week. Your doctor may adjust your dose as needed.
    - Minivelle® and Vivelle-Dot®: At first, apply one patch (0.025 milligrams (mg)) to the lower stomach or upper buttock area 2 times a week (every 3 to 4 days). Your doctor may adjust your dose as needed.
  - Children—Use is not recommended.
For the treatment of low estrogen levels:
- For transdermal dosage form (patch):
  - Adults—At first, apply one patch (0.025 milligrams (mg)) to the lower stomach or upper buttock area once a week. Your doctor may adjust your dose as needed.
  - Children—Use is not recommended.

Missed dose

If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Do not use Evamist® spray if it has been more than 12 hours since you missed your last dose.

Storage

Store the patches at room temperature in a closed container, away from heat, moisture, and direct light.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Estradiol dosage information

Precautions while using Vivelle 100 Mcg

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. These visits may be every 3 to 6 months. Pelvic exam, breast exam, and mammogram (breast x-ray) may be needed to check for unwanted effects, unless your doctor tells you otherwise. Be sure to keep all appointments.

It is unlikely that a postmenopausal woman may become pregnant. But, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. This risk may continue even after you stop using the medicine. Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol in your blood, diabetes, or if you are overweight or smoke cigarettes. Contact your doctor immediately if you experience confusion, difficulty speaking, double vision, headaches, an inability to move arms, legs or facial muscle, or an inability to speak.

Using this medicine over a long period of time may increase your risk of breast cancer, endometrial cancer, or uterine cancer. Do not use this medicine if you have had your uterus (womb) removed (hysterectomy). Check with your doctor immediately if you experience abnormal vaginal bleeding.

Using this medicine may increase your risk of dementia, especially in women 65 years of age and older.

Using this medicine may increase your risk for gallbladder disease. Talk with your doctor about this risk.

Tell the medical doctor or dentist in charge that you are using this medicine before any kind of surgery (including dental surgery) or emergency treatment. Your doctor will decide whether you should continue using this medicine. This medicine may also affect the results of certain medical tests.

Check with your doctor immediately if severe headache or sudden loss of vision or any other change in vision occurs while you are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Check with your child''s doctor right away if your child starts to have nipple or breast swelling or tenderness in females, or enlargement of the breasts in males. Your child may have been exposed to this medicine.

Do not allow your pets to lick or touch the arm where this medicine was applied. Small pets may be sensitive to this medicine. Call your pet''s veterinarian if your pet starts to have nipple or breast enlargement, swelling of the vulva, or any signs of illness.

Do not take other medicines or drink grapefruit juice unless you discuss it with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John''s wort) or vitamin supplements.

Vivelle 100 Mcg side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Acid or sour stomach
anxiety
backache
belching
blistering, peeling, or loosening of the skin
bloating
blurred vision
breast tenderness, enlargement, pain, or discharge
change in vaginal discharge
changes in skin color
changes in vision
chest pain, discomfort, or tightness
chills
clay-colored stools
clear or bloody discharge from the nipple
confusion
constipation
cough
darkening of the urine
diarrhea
difficulty with swallowing
dimpling of the breast skin
dizziness or lightheadedness
double vision
fainting
fast heartbeat
fever
fluid-filled skin blisters
full or bloated feeling or pressure in the stomach
headache
headache, severe and throbbing
heartburn
hives, itching, skin rash
indigestion
inverted nipple
irregular heartbeat
itching of the vagina or genital area
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
loss of appetite
loss of bladder control
lump in the breast or under the arm
migraine headache
mood or mental changes
muscle cramps in the hands, arms, feet, legs, or face
muscle spasm or jerking of all extremities
nausea
noisy breathing
numbness and tingling around the mouth, fingertips, or feet
pain during sexual intercourse
pain in the ankles or knees
pain or discomfort in the arms, jaw, back, or neck
pain or feeling of pressure in the pelvis
pain, redness, or swelling in the arm, foot, or leg
painful, red lumps under the skin, mostly on the legs
pains in the stomach, side, or abdomen, possibly radiating to the back
persistent crusting or scaling of the nipple
poor insight and judgment
problems with memory or speech
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red, irritated eyes
redness or swelling of the breast
seizures
sensitivity to the sun
skin thinness
sore on the skin of the breast that does not heal
sore throat
sores, ulcers, or white spots in the mouth or on the lips
stomach cramps, discomfort, upset, pain, or swelling
sudden loss of consciousness
sudden trouble breathing
sweating
thick, white vaginal discharge with no odor or with a mild odor
tremor
trouble recognizing objects
trouble thinking and planning
trouble walking
unexpected or excess milk flow from the breasts
unpleasant breath odor
unusual tiredness or weakness
unusually heavy or unexpected menstrual bleeding
vaginal bleeding or spotting
vomiting
vomiting of blood
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Back pain
difficulty with moving
muscle aches, pain, or stiffness
stuffy or runny nose

Incidence not known

Decreased interest in sexual intercourse
heavy bleeding
increased hair growth, especially on the face
increased in sexual ability, desire, drive, or performance
increased interest in sexual intercourse
irritability
leg cramps
loss in sexual ability, desire, drive, or performance
loss of scalp hair
mental depression
mood disturbances
patchy brown or dark brown discoloration of the skin
redness of the skin
twitching, uncontrolled movements of the tongue, lips, face, arms, or legs
weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Estradiol side effects (more detail)

More about estradiol

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Drug class: estrogens
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Drug Information
Estradiol injection
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Estradiol transdermal skin patch
Estradiol vaginal

Other brands

Estrace, Estradiol Patch, Climara, Estrogel, ... +18 more

Professional resources

Prescribing Information

Related treatment guides

Atrophic Vaginitis
Gender Affirming Hormone Therapy
Atrophic Urethritis
Breast Cancer, Palliative

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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Vivelle 25 Mcg

Generic name: estrogen (oral route, parenteral route, topical application route, transdermal route)

Commonly used brand name(s)

In the U.S.

Alora
Cenestin
Climara
Divigel
Elestrin
Emcyt
Enjuvia
Esclim
Estinyl
EstroGel
Evamist
Femtrace
Gynodiol
Menest
Menostar
Minivelle
Ogen .625
Ogen 1.25
Ogen 2.5
Premarin
Vivelle
Vivelle-Dot

In Canada

Estraderm
Estradot Transdermal
Estradot Transdermal Therapeutic System
Estradot Transdermal Therapeutic System
Estrogel
Oesclim
Rhoxal-Estradiol Derm 50
Rhoxal-Estradiol Derm 75
Roxal-Estradiol Derm 100
Vivelle 100 Mcg
Vivelle 25 Mcg

Available Dosage Forms:

Patch, Extended Release
Gel/Jelly
Tablet
Spray
Capsule

Uses for Vivelle 25 Mcg

Estrogens are female hormones. They are produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years.

The ovaries begin to produce less estrogen after menopause (the change of life). This medicine is prescribed to make up for the lower amount of estrogen. Estrogens help relieve signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness.

Estrogens are prescribed for several reasons:

To provide additional hormone when the body does not produce enough of its own, such as during menopause or when female puberty (development of female sexual organs) does not occur on time. Other conditions include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or ovary problems (female hypogonadism or failure or removal of both ovaries).
To help prevent weakening of bones (osteoporosis) in women past menopause.
In the treatment of selected cases of breast cancer in men and women.
In the treatment of cancer of the prostate in men.

Estrogens may also be used for other conditions as determined by your doctor.

There is no medical evidence to support the belief that the use of estrogens will keep the patient feeling young, keep the skin soft, or delay the appearance of wrinkles. Nor has it been proven that the use of estrogens during menopause will relieve emotional and nervous symptoms, unless these symptoms are caused by other menopausal symptoms, such as hot flashes or hot flushes.

Estrogens are available only with your doctor''s prescription.

Before using Vivelle 25 Mcg

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of this medicine before puberty is not recommended. Growth of bones can be stopped early. Girls and boys may develop growth of breasts. Girls may have vaginal changes, including vaginal bleeding.

This medicine may be used to start puberty in teenagers with some types of delayed puberty.

Geriatric

Elderly people are especially sensitive to the effects of estrogens. This may increase the chance of side effects during treatment, especially stroke, invasive breast cancer, and memory problems.

Pregnancy

Estrogens are not recommended for use during pregnancy or right after giving birth. Becoming pregnant or maintaining a pregnancy is not likely to occur around the time of menopause.

Certain estrogens have been shown to cause serious birth defects in humans and animals. Some daughters of women who took diethylstilbestrol (DES) during pregnancy have developed reproductive (genital) tract problems and, rarely, cancer of the vagina or cervix (opening to the uterus) when they reached childbearing age. Some sons of women who took DES during pregnancy have developed urinary-genital tract problems.

Breastfeeding

Use of this medicine is not recommended in nursing mothers. Estrogens pass into the breast milk and their possible effect on the baby is not known.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Dasabuvir
Ombitasvir
Paritaprevir
Ritonavir
Tranexamic Acid

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Amifampridine
Amoxicillin
Ampicillin
Amprenavir
Anagrelide
Apalutamide
Aprepitant
Armodafinil
Artemether
Bacampicillin
Belzutifan
Betamethasone
Bexarotene
Boceprevir
Bosentan
Bupropion
Carbamazepine
Carbenicillin
Cefaclor
Cefadroxil
Cefdinir
Cefditoren
Cefixime
Cefpodoxime
Cefprozil
Ceftazidime
Ceftibuten
Cefuroxime
Cenobamate
Ceritinib
Clavulanic Acid
Clobazam
Cloxacillin
Colesevelam
Conivaptan
Cyclacillin
Cyclosporine
Dabrafenib
Darunavir
Dexamethasone
Dicloxacillin
Donepezil
Doxycycline
Efavirenz
Elagolix
Elvitegravir
Encorafenib
Enzalutamide
Eslicarbazepine Acetate
Etravirine
Fedratinib
Fexinidazole
Fosamprenavir
Fosaprepitant
Fosnetupitant
Fosphenytoin
Fostemsavir
Glecaprevir
Griseofulvin
Guar Gum
Iron
Isotretinoin
Ivosidenib
Lesinurad
Lixisenatide
Lorlatinib
Lumacaftor
Mavacamten
Minocycline
Mitapivat
Mitotane
Mobocertinib
Modafinil
Mycophenolate Mofetil
Mycophenolic Acid
Nafcillin
Nelfinavir
Netupitant
Nevirapine
Nirmatrelvir
Octreotide
Oxacillin
Oxcarbazepine
Oxytetracycline
Paclitaxel
Paclitaxel Protein-Bound
Penicillin G
Penicillin G Procaine
Penicillin V
Phenobarbital
Phenylbutazone
Phenytoin
Pibrentasvir
Piperaquine
Pitolisant
Pixantrone
Prednisone
Primidone
Red Clover
Rifabutin
Rifampin
Rifapentine
Ritonavir
Rufinamide
Secobarbital
St John''s Wort
Sugammadex
Sultamicillin
Tazemetostat
Telaprevir
Tetracycline
Theophylline
Ticarcillin
Tigecycline
Tirzepatide
Tizanidine
Topiramate
Troglitazone
Ulipristal
Valproic Acid

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper use of Vivelle 25 Mcg

This section provides information on the proper use of a number of products that contain estrogen. It may not be specific to Vivelle 25 Mcg. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it and do not take or use it for a longer time than your doctor ordered. For patients taking any of the estrogens by mouth, try to take the medicine at the same time each day to reduce the possibility of side effects and to allow it to work better.

This medicine usually comes with patient information or directions. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

For patients taking any of the estrogens by mouth or by injection:

Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food.

For patients using the transdermal (skin patch):

Wash and dry your hands thoroughly before and after handling the patch.
Apply the patch to a clean, dry, non-oily skin area of your lower abdomen, hips below the waist, or buttocks that has little or no hair and is free of cuts or irritation. The manufacturer of the 0.025-mg patch recommends that its patch be applied to the buttocks only. Furthermore, each new patch should be applied to a new site of application. For instance, if the old patch is taken off the left buttock, then apply the new patch to the right buttock.
Do not apply to the breasts. Also, do not apply to the waistline or anywhere else where tight clothes may rub the patch loose.
Press the patch firmly in place with the palm of your hand for about 10 seconds. Make sure there is good contact, especially around the edges.
If a patch becomes loose or falls off, you may reapply it or discard it and apply a new patch.
Each dose is best applied to a different area of skin on your lower abdomen, hips below the waist, or buttocks so that at least 1 week goes by before the same area is used again. This will help prevent skin irritation.

For patients using the topical emulsion (skin lotion):

Washing and drying hands thoroughly before each application.
Apply while you are sitting comfortably. Apply one pouch to each leg every morning.
Apply the entire contents of one pouch to clean, dry skin on the left thigh. Rub the emulsion into the entire thigh and calf for 3 minutes until thoroughly absorbed.
Apply entire contents of the second pouch to clean, dry skin on the right thigh. Rub the emulsion into the entire thigh and calf for 3 minutes until thoroughly absorbed.
Rub any remaining emulsion on both hands on the buttocks.
Washing and drying hands thoroughly after application.
To avoid transfer to other individuals, allow the application areas to dry completely before covering with clothing.

If you are using the Evamist® transdermal spray:

Spray the medicine on your skin on the inside of your forearm, between the elbow and the wrist.
Do not allow your child to touch the area of the arm where the medicine was sprayed. If you cannot avoid to come nearer with your child, wear clothes with long sleeves to cover the application site.
If your child comes in direct contact with the arm where the medicine was sprayed, wash your child''s skin right away with soap and water.
Do not allow your pets to lick or touch the arm where the medicine was sprayed.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor''s orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

For oral dosage form (tablets):
- For treating breast cancer in women after menopause and in men:
  - Adults—10 milligrams (mg) three times a day for at least 3 months.
- For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
  - Adults—0.3 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may change the dose based on how your body responds to the medication.
- To prevent loss of bone (osteoporosis):
  - Adults—0.3 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may change the dose based on how your body responds to the medication.
- For treating ovary problems (female hypogonadism or for starting puberty):
  - Adults and teenagers—0.3 to 0.625 milligram (mg) a day. Your doctor may want you to take the medicine only on certain days of the month.
- For treating ovary problems (failure or removal of both ovaries):
  - Adults—1.25 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating prostate cancer:
  - Adults—1.25 to 2.5 milligram (mg) three times a day.
For injection dosage form:
- For controlling abnormal bleeding of the uterus:
  - Adults—25 milligrams (mg) injected into a muscle or vein. This may be repeated in six to twelve hours if needed.

For oral dosage form (tablets):
- For treating breast cancer in women after menopause and in men:
  - Adults—10 milligrams (mg) three times a day for at least three months.
- For treating a genital skin condition (vulvar atrophy) or inflammation of the vagina (atrophic vaginitis), or to prevent loss of bone (osteoporosis):
  - Adults—0.3 to 1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating ovary problems (failure or removal of both ovaries):
  - Adults—1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating ovary problems (female hypogonadism):
  - Adults—2.5 to 7.5 mg a day. This dose may be divided up and taken in smaller doses. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating symptoms of menopause:
  - Adults—0.625 to 1.25 mg a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating prostate cancer:
  - Adults—1.25 to 2.5 mg three times a day.

For oral dosage form:
- For treating breast cancer in women after menopause and in men:
  - Adults—10 milligrams (mg) three times a day for at least 3 months.
- For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), ovary problems (female hypogonadism or failure or removal of both ovaries), or symptoms of menopause:
  - Adults—At first, 1 to 2 milligrams (mg) one time per day for at least 3 months. Your doctor may want you to take the medicine each day or only on certain days of the month. Your doctor may also need to change the dose based on how your body responds to the medication.
- For treating prostate cancer:
  - Adults—1 to 2 milligrams (mg) three times a day.
- To prevent loss of bone (osteoporosis):
  - Adults—0.5 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
For topical emulsion dosage form (skin lotion):
- For treating symptoms of menopause:
  - Adults—1.74 grams (one pouch) applied to the skin of each leg (thigh and calf) once a day in the morning.
For transdermal dosage form (skin patches):
- For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), symptoms of menopause, ovary problems (female hypogonadism or failure or removal of both ovaries), or to prevent loss of bone (osteoporosis):
  - Adults—0.025 to 0.1 milligram (mg) (one patch) applied to the skin and worn for one week. Then, remove that patch and apply a new one. A new patch should be applied once a week for three weeks. During the fourth week, you may or may not wear a patch. Your health care professional will tell you what you should do for this fourth week. After the fourth week, you will repeat the cycle.
  - Adults—0.025 to 0.1 mg (one patch) applied to the skin and worn for one half of a week. Then, remove that patch and apply and wear a new patch for the rest of the week. A new patch should be applied two times a week for three weeks. During the fourth week, you may or may not apply new patches. Your health care professional will tell you what you should do for this fourth week. After the fourth week, you will repeat the cycle.

For injection dosage form:
- For treating ovary problems (female hypogonadism):
  - Adults—1.5 to 2 milligrams (mg) injected into a muscle once a month.
- For treating symptoms of menopause:
  - Adults—1 to 5 milligrams (mg) injected into a muscle every 3 to 4 weeks.

For injection dosage form:
- For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), symptoms of menopause, or ovary problems (female hypogonadism or failure or removal of both ovaries):
  - Adults—10 to 20 milligrams (mg) injected into a muscle every 4 weeks as needed.
- For treating prostate cancer:
  - Adults—30 milligrams (mg) injected into a muscle every 1 or 2 weeks.

For injection dosage form:
- For controlling abnormal bleeding of the uterus:
  - Adults—2 to 5 milligrams (mg) a day, injected into a muscle for several days.
- For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
  - Adults—0.1 to 0.5 milligram (mg) injected into a muscle 2 or 3 times a week. Your doctor may want you to receive the medicine each week or only during certain weeks of the month.
- For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
  - Adults—0.1 to 1 milligram (mg) a week. This is injected into a muscle as a single dose or divided into more than one dose. Your doctor may want you to receive the medicine each week or only during certain weeks of the month.
- For treating prostate cancer:
  - Adults—2 to 4 milligrams (mg) injected into a muscle 2 or 3 times a week.

For oral dosage form (tablets):
- For treating a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), or symptoms of menopause:
  - Adults—0.75 to 6 milligrams (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
  - Adults—1.5 to 9 milligrams (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.
- To prevent loss of bone (osteoporosis):
  - Adults—0.75 milligram (mg) a day. Your doctor may want you to take the medicine each day for twenty-five days of a thirty-one–day cycle.

For oral dosage form (tablets):
- For treating breast cancer in women after menopause and in men:
  - Adults—1 milligram (mg) three times a day.
- For treating ovary problems (female hypogonadism or failure or removal of both ovaries):
  - Adults—0.05 milligram (mg) one to three times a day for 3 to 6 months. Your doctor may want you to take the medicine each day or only on certain days of the month.
- For treating prostate cancer:
  - Adults—0.15 to 3 milligrams (mg) a day.
- For treating symptoms of menopause:
  - Adults—0.02 to 0.05 milligram (mg) a day. Your doctor may want you to take the medicine each day or only on certain days of the month.

For oral dosage form (tablets):
- For treating symptoms of menopause:
  - Adults—1 tablet (5 mcg ethinyl estradiol and 1 mg of norethindrone) each day.
- To prevent loss of bone (osteoporosis):
  - Adults—1 tablet (5 mcg ethinyl estradiol and 1 mg of norethindrone) each day.

Missed dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using Vivelle 25 Mcg

It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects. These visits will usually be every year, but some doctors require them more often.

In some patients using estrogens, tenderness, swelling, or bleeding of the gums may occur. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your medical doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums.

Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast, ovaries, or uterus (womb). Therefore, it is very important that you regularly check your breasts for any unusual lumps or discharge. Report any problems to your doctor. You should also have a mammogram (x-ray pictures of the breasts) done if your doctor recommends it. Because breast cancer has occurred in men taking estrogens, regular breast self-exams and exams by your doctor for any unusual lumps or discharge should be done.

If your menstrual periods have stopped, they may start again. This effect will continue for as long as the medicine is taken. However, if taking the continuous treatment (0.625 mg conjugated estrogens and 2.5 mg medroxyprogesterone once a day), monthly bleeding usually stops within 10 months.

Also, vaginal bleeding between your regular menstrual periods may occur during the first 3 months of use. Do not stop taking your medicine. Check with your doctor if bleeding continues for an unusually long time, if your period has not started within 45 days of your last period, or if you think you are pregnant.

Tell the doctor in charge that you are using this medicine before having any laboratory test because some results may be affected.

Check with your child''s doctor right away if your child starts to have the following symptoms: nipple or breast swelling or tenderness in females, or enlargement of the breasts in males. Your child may have been exposed to Evamist® transdermal spray.

Do not allow your pets to lick or touch the arm where Evamist® transdermal spray was applied. Small pets may be sensitive to this medicine. Call your pet''s veterinarian if your pet starts to have the following symptoms: nipple or breast enlargement, swelling of the vulva, or any signs of illness.

Vivelle 25 Mcg side effects

Women rarely have severe side effects from taking estrogens to replace estrogen. Discuss these possible effects with your doctor:

The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. This risk seems to increase as the dose and the length of use increase. When estrogens are used in low doses for less than 1 year, there is less risk. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer.

Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast. Breast cancer has been reported in men taking estrogens.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

The following side effects may be caused by blood clots, which could lead to stroke, heart attack, or death. These side effects occur rarely, and, when they do occur, they occur in men treated for cancer using high doses of estrogens.

Check with your doctor immediately if any of the following side effects occur:

More common

Breast pain (in females and males)
fast heartbeat
fever
hives
hoarseness
increased breast size (in females and males)
irritation of the skin
itching of the skin
joint pain, stiffness, or swelling
rash
redness of the skin
shortness of breath
swelling of the eyelids, face, lips, hands, or feet
swelling of the feet and lower legs
tightness in the chest
troubled breathing or swallowing
weight gain (rapid)
wheezing

Less common or rare

Changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding)
chest pain
chills
cough
heavy non-menstrual vaginal bleeding
lumps in, or discharge from, breast (in females and males)
pains in the stomach, side, or abdomen
yellow eyes or skin

Rare

- for males being treated for breast or prostate cancer only

Headache (sudden or severe)
loss of coordination (sudden)
loss of vision or change of vision (sudden)
pains in the chest, groin, or leg, especially in the calf of leg
shortness of breath (sudden and unexplained)
slurring of speech (sudden)
weakness or numbness in the arm or leg

Incidence not known

Abdominal or stomach bloating
abdominal or stomach cramps
acid or sour stomach
anxiety
backache
belching
blindness
blistering, peeling, or loosening of the skin
blue-yellow color blindness
blurred vision
change in vaginal discharge
changes in skin color
changes in vision
chest discomfort
clay-colored stools
clear or bloody discharge from nipple
confusion
constipation
convulsions
dark urine
decrease in the amount of urine
decreased vision
depression
diarrhea
difficulty with breathing
difficulty with speaking
dimpling of the breast skin
dizziness
double vision
dry mouth
eye pain
fainting
fluid-filled skin blisters
full feeling in upper abdomen or stomach
full or bloated feeling or pressure in the stomach
headache
heartburn
inability to move the arms, legs, or facial muscles
inability to speak
incoherent speech
increased urination
indigestion
inverted nipple
irregular heartbeats
light-colored stools
lightheadedness
loss of appetite
loss of bladder control
lump under the arm
metallic taste
migraine headache
mood or mental changes
muscle cramps in the hands, arms, feet, legs, or face
muscle pain
muscle spasm or jerking of all extremities
muscle weakness
nausea
noisy breathing
numbness or tingling of the hands, feet, or face
pain in the ankles or knees
pain or discomfort in the arms, jaw, back or neck
pain or feeling of pressure in the pelvis
pain, tenderness, swelling of the foot or leg
painful or tender cysts in the breasts
painful, red lumps under the skin, mostly on the legs
pains in the chest, groin, or legs, especially calves of the legs
partial or complete loss of vision in the eye
pelvic pain
persistent crusting or scaling of nipple
pinpoint red or purple spots on the skin
prominent superficial veins over affected area
red, irritated eyes
redness or swelling of the breast
sensitivity to the sun
severe headaches of sudden onset
skin thinness
skin warmth
slow speech
sore on the skin of the breast that does not heal
sore throat
sores, ulcers, or white spots in the mouth or on the lips
stomach discomfort, upset, or pain
sudden loss of consciousness
sudden loss of coordination
sudden onset of shortness of breath for no apparent reason
sudden onset of slurred speech
sudden vision changes
swelling of the abdominal or stomach area
swelling of the fingers or hands
thirst
tremor
unpleasant breath odor
unusual tiredness or weakness
vomiting
vomiting of blood
weight loss

More common

Abnormal growth filled with fluid or semisolid material
accidental injury
bladder pain
bloated full feeling
bloody or cloudy urine
body aches or pain
coating or white patches on tongue
congestion
cough producing mucus
decrease in amount of urine
difficult, burning, or painful urination
discouragement
dryness of the throat
ear congestion or pain
excess air or gas in the stomach or intestines
fear
feeling of warmth
feeling sad or empty
frequent urge to urinate
general feeling of discomfort or illness
headache, severe and throbbing
increased clear or white vaginal discharge
irritability
itching of the vaginal, rectal or genital areas
lack of appetite
lack or loss of strength
loss of interest or pleasure
mild dizziness
neck pain
nervousness
pain
pain during sexual intercourse
painful or difficult urination
pain or tenderness around the eyes and cheekbones
passing gas
redness of the face, neck, arms, and occasionally, upper chest
runny nose
skin irritation or redness where skin patch was worn
shivering
sleeplessness
sneezing
sore mouth or tongue
stuffy nose
sudden sweating
tender, swollen glands in the neck
thick, white vaginal discharge with no odor or with a mild odor
tiredness
trouble concentrating
trouble sleeping
unable to sleep
voice changes

Less common

Blemishes on the skin
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
burning or stinging of the skin
diarrhea (mild)
difficulty with moving
dizziness (mild)
increased hair growth, especially on the face
lower abdominal or stomach pain or pressure
mood or mental changes
muscle stiffness
painful cold sores or blisters on the lips, nose, eyes, or genitals
pimples
pounding in the ears
problems in wearing contact lenses
slow heartbeat
tooth or gum pain
unusual decrease in sexual desire (in males)
unusual increase in sexual desire (in females)
white or brownish vaginal discharge

Incidence not known

Abnormal turning out of cervix
changes in appetite
dull ache or feeling of pressure or heaviness in the legs
flushed, dry skin
fruit-like breath odor
increased hunger
irritability
large amount of triglyceride in the blood
leg cramps
patchy brown or dark brown discoloration of the skin
poor insight and judgment
problems with memory or speech
trouble recognizing objects
trouble thinking and planning
trouble walking
twitching, uncontrolled movements of the tongue, lips, face, arms, or legs
unexpected or excess milk flow from the breasts

Also, many women who are taking estrogens with a progestin (another female hormone) will start having monthly vaginal bleeding, similar to menstrual periods, again. This effect will continue for as long as the medicine is taken. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (total hysterectomy).

This medicine may cause loss or thinning of the scalp hair in some people.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drug name: Vivelle 100 Mcg (Transdermal)

Vivelle 100 Mcg (Transdermal)

Commonly used brand name(s)

Related/similar drugs

Uses for Vivelle 100 Mcg

Before using Vivelle 100 Mcg

Allergies

Pediatric

Geriatric

Breastfeeding

Interactions with medicines

Interactions with food/tobacco/alcohol

Other medical problems

Proper use of Vivelle 100 Mcg

Dosing

Missed dose

Storage

Precautions while using Vivelle 100 Mcg

Vivelle 100 Mcg side effects

More about estradiol

Patient resources

Other brands

Professional resources

Related treatment guides

Further information

Vivelle 25 Mcg

Commonly used brand name(s)

Uses for Vivelle 25 Mcg

Before using Vivelle 25 Mcg

Allergies

Pediatric

Geriatric

Pregnancy

Breastfeeding

Interactions with medicines

Interactions with food/tobacco/alcohol

Other medical problems

Proper use of Vivelle 25 Mcg

Dosing

Missed dose

Storage

Precautions while using Vivelle 25 Mcg

Vivelle 25 Mcg side effects

Further information