Generic name: loxapine (inhalation) [ LOX-a-peen ]
Drug class: Miscellaneous antipsychotic agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 26, 2022.

What is Adasuve inhalation?

Adasuve is an antipsychotic medication that affects the actions of chemicals in your brain.

Adasuve inhalation powder is used to treat agitation related to schizophrenia or bipolar disorder.

Adasuve inhalation is given only in a hospital or clinic setting where any breathing problems can be quickly treated.

Warnings

You should not use Adasuve inhalation if you have breathing problems that can cause bronchospasm (such as asthma or COPD), or if you are currently having trouble breathing with cough and wheezing. You should not use this medicine if you have ever had breathing problems after using it in the past.

Adasuve inhalation can cause bronchospasm (wheezing, chest tightness, shortness of breath) that can lead to serious lung problems or make your breathing stop. This medicine must be given in a hospital or clinic setting where your doctor can quickly treat any serious side effects that occur.

This medicine is not approved for use in older adults with dementia-related psychosis.

Before taking this medicine

You should not be treated with Adasuve if you are allergic to loxapine or amoxapine, or if you have:

• trouble breathing with cough and wheezing;

• a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung problems;

• a breathing disorder you are currently treating with medication; or

• a history of having bronchospasm after using Adasuve inhalation.

Loxapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

To make sure Adasuve is safe for you, tell your doctor if you have ever had:

• epilepsy or other seizure disorder;

• high or low blood pressure;

• glaucoma;

• urination problems;

• Parkinson''s disease;

• heart disease;

• a heart attack or stroke; or

• if you drink alcohol or use street drugs.

Tell your doctor if you are pregnant or you get pregnant. Using antipsychotic medication during the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.

You should not breastfeed while using Adasuve.

How is Adasuve given?

Adasuve inhalation is usually given once every 24 hours as needed.

A healthcare provider will give you this medicine in a hospital or clinic setting where you can be quickly treated if any serious side effects occur.

A healthcare provider can teach you how to properly use the Adasuve inhaler device.

The inhaler device has a green indicator light on one side and a pull tab at one end. When the pull tab is released the green light will turn on, showing that the device is ready for use.

Once the green light turns on, you must use the inhaler within 15 minutes or the device will deactivate. Do not try to use the inhaler if the green light is off.

While using the Adasuve inhaler device, you may hear a clicking sound and the device may feel warm. These are normal functions. After you have inhaled your dose, the green light will turn off to show that the entire dose has been used.

You will be watched closely for at least 1 hour after using Adasuve, to make sure you do not have any breathing problems.

Dosing information

Use: For the treatment of schizophrenia. Usual Adult Dose for Agitated State:

10 mg by oral inhalation once within a 24-hour period

Comments:
-To mitigate the risk of bronchospasm, all patients must undergo screening and examination prior to administration.
-This drug must be administered by a healthcare professional only in an enrolled healthcare facility.

Use: For the acute treatment of agitation associated with schizophrenia or bipolar I disorder

What happens if I miss a dose?

Since Adasuve inhalation is used when needed, you may need only one dose. Adasuve is usually not given more than once in a 24-hour period.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Adasuve?

Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

Do not drink alcohol. Dangerous side effects could occur.

Adasuve side effects

Get emergency medical help if you have signs of an allergic reaction to Adasuve: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

• a light-headed feeling, like you might pass out;

• blurred vision, tunnel vision, eye pain, or seeing halos around lights;

• bronchospasm (wheezing, cough, chest tightness, trouble breathing);

• little or no urination;

• a seizure (convulsions); or

• severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common Adasuve side effects may include:

• drowsiness;

• sore throat; or

• an unusual or unpleasant taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adasuve?

Using Adasuve with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

• medicine to treat depression, anxiety, mood disorders, or mental illness;

• cold or allergy medicine (Benadryl and others);

• medicine to treat Parkinson''s disease;

• medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

• medicine to treat overactive bladder; or

• bronchodilator asthma medication.

This list is not complete. other drugs may interact with loxapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Adasuve only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 2.01.

Adbry

Generic name: tralokinumab-ldrm
Dosage form: injection, for subcutaneous use
Drug class: Interleukin inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Dec 30, 2021.

What is Adbry?

• Adbry is a prescription medicine used to treat adults with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. Adbry can be used with or without topical corticosteroids.
• It is not known if Adbry is safe and effective in children.

Who should not use Adbry?

Do not use Adbry if you are allergic to tralokinumab or to any of the ingredients. See the end of this page for a complete list of ingredients.

Before using Adbry

Before you start treatment, tell your healthcare provider about all your medical conditions, including if you:

• have eye problems.
• have a parasitic (helminth) infection.
• are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with Adbry.
• are pregnant or plan to become pregnant. It is not known whether Adbry will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known whether Adbry passes into your breast milk and if it can harm your baby.

What other drugs will affect Adbry?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use Adbry?

• See the detailed Instructions for Use that comes with your prescription for information on how to prepare and inject Adbry and how to properly store and throw away (dispose of) used Adbry prefilled syringes.
• Use Adbry exactly as prescribed by your healthcare provider.
• Your healthcare provider will tell you how much Adbry to inject and when to inject it.
• Adbry comes as a single-dose (150 mg) prefilled syringe with needle guard.
• Adbry is given as an injection under the skin (subcutaneous injection).
• If your healthcare provider decides that you or a caregiver can give the injections, you or your caregiver should receive training on the right way to prepare and inject Adbry. Do not try to inject Adbry until you have been shown the right way by your healthcare provider.
• If you miss a dose, inject the missed dose as soon as possible, then continue with your next dose at your regular scheduled time.
• If you inject more Adbry than prescribed, call Poison Control at 1-800-222-1222.
• Your healthcare provider may prescribe other medicines to use with Adbry. Use the other prescribed medicines exactly as your healthcare provider tells you to.

Dosage information

Usual Adult Dosage for Atopic Dermatitis

- initial dose of 600 mg (four 150 mg injections), followed by 300 mg (two 150 mg injections) administered every other week. A dosage of 300 mg every 4 weeks may be considered for patients below 100 kg who achieve clear or almost clear skin after 16 weeks of treatment.

- Use: treatment of moderate-to-severe atopic dermatitis in adult patients whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

Adbry side effects

Adbry can cause serious side effects, including:

• Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Stop using Adbry and tell your healthcare provider or get emergency help right away if you get any of the following symptoms:
  • breathing problems
  • swelling of the face, mouth, and tongue
  • hives
  • itching
  • fainting, dizziness, feeling lightheaded (low blood pressure)
  • skin rash
• Eye problems. Tell your healthcare provider if you have any worsening eye problems, including eye pain or changes in vision.

The most common side effects include:

• eye and eyelid inflammation, including redness, swelling, and itching
• injection site reactions
• high count of a certain white blood cell (eosinophilia)

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of Adbry

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use this medicine for a condition for which it was not prescribed. Do not give it to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Adbry?

Active ingredient: tralokinumab-ldrm
Inactive ingredients: acetic acid, polysorbate 80, sodium acetate trihydrate, sodium chloride, and water for injection.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer