Voxelotor

Generic name: voxelotor [ vox-EL-oh-tor ]
Brand name: Oxbryta
Dosage form: oral tablet (500 mg)
Drug class: Miscellaneous uncategorized agents

Medically reviewed by Drugs.com on Dec 26, 2022. Written by Cerner Multum.

What is voxelotor?

Voxelotor is used to treat sickle cell disease in adults and children at least 12 years old.

Voxelotor is sometimes given together with another medicine called hydroxyurea.

Voxelotor was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to voxelotor, but further studies are needed.

Voxelotor may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use voxelotor if you are allergic to it.

Tell your doctor if you have ever had:

• liver disease;

It is not known whether voxelotor will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Voxelotor is not approved for use by anyone younger than 12 years old.

How should I take voxelotor?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take voxelotor with or without food.

Swallow the tablet whole and do not crush, chew, or break it.

If you are receiving exchange transfusions, voxelotor can affect the results of certain blood tests. Tell any doctor who treats you that you are using voxelotor.

You should not stop using voxelotor without your doctor''s advice.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking voxelotor?

Follow your doctor''s instructions about any restrictions on food, beverages, or activity.

Voxelotor side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of voxelotor may include:

• headache;

• stomach pain, nausea, diarrhea;

• tiredness;

• rash; or

• fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Voxelotor dosing information

Usual Adult Dose for Sickle Cell Anemia:

1500 mg orally once a day

Comment:
-This drug may be given with or without hydroxyurea.

Use: For the treatment of sickle cell disease.

Usual Pediatric Dose for Sickle Cell Anemia:

4 to less than 12 years:
-Weight: 10 to less than 20 kg: 600 mg orally once a day
-Weight: 20 to less than 40 kg: 900 mg orally once a day
-Weight 40 kg or greater: 1500 mg orally once a day

12 years or older: 1500 mg orally once a day

Comment:
-This drug may be given with or without hydroxyurea.

Use: For the treatment of sickle cell disease in patients 4 years or older.

What other drugs will affect voxelotor?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect voxelotor. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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