Xylocaine HCl

Generic name: lidocaine injection [ LYE-doe-kane ]
Brand names: Xylocaine HCl, Xylocaine-MPF
Drug classes: Group I antiarrhythmics, Local injectable anesthetics

Medically reviewed by Drugs.com on Sep 13, 2022. Written by Cerner Multum.

What is Xylocaine HCl?

Lidocaine is a local anesthetic (numbing medication) that is used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube.

Xylocaine HCl is sometimes used to treat irregular heart rhythms that may signal a possible heart attack.

Xylocaine HCl is also given in an epidural (spinal block) to reduce the discomfort of contractions during labor.

Xylocaine HCl may also be used for purposes not listed in this medication guide.

Warnings

You should not receive Xylocaine HCl if you have severe heart block, or a heart rhythm disorder called Stokes-Adams syndrome or Wolff-Parkinson-White Syndrome.

Before taking this medicine

You should not receive this medicine if you are allergic to Xylocaine HCl or any other type of numbing medicine, or if you have:

• severe heart block;

• a heart rhythm disorder called Stokes-Adams syndrome (sudden slow heart beats that can cause you to faint); or

• a heart rhythm disorder called Wolff-Parkinson-White Syndrome (sudden fast heartbeats that can cause you to faint or become easily tired).

Tell your doctor if you have ever had:

• an allergy to corn products;

• liver disease;

• kidney disease;

• heart disease (unless you are being treated with Xylocaine HCl for a heart condition);

• coronary artery disease, circulation problems; or

• malignant hyperthermia.

Tell your doctor if you are pregnant or breastfeeding.

How is Xylocaine HCl given?

A healthcare provider will give you this injection.

When used to treat heart rhythm problems, lidocaine is given as an infusion into a vein.

When used as a local anesthetic, lidocaine is injected through the skin directly into the body area to be numbed.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving Xylocaine HCl in a hospital setting.

If you are being treated for irregular heart rhythm, your heart rate will be constantly monitored using an electrocardiograph or ECG (sometimes called an EKG). This will help your doctor determine how long to treat you with Xylocaine HCl.

What happens if I miss a dose?

Since Xylocaine HCl is used only when needed in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving Xylocaine HCl?

Xylocaine HCl can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after receiving Xylocaine HCl.

Avoid eating or chewing within 1 hour after Xylocaine HCl is used to numb your mouth or throat. You may have trouble swallowing which could lead to choking. You may also accidentally bite the inside of your mouth if you are still numb an hour after treatment with this medicine.

Xylocaine HCl side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

• twitching, tremors, seizure (convulsions);

• a light-headed feeling, like you might pass out;

• slow heart rate, weak pulse, weak or shallow breathing;

• sudden feeling of heat, cold, or numbness;

• muscle stiffness and pain;

• weak or shallow breathing;

• blue appearance of the skin; or

• severe anxiety, unusual fear or uneasy feeling.

Common side effects of Xylocaine HCl may include:

• drowsiness, dizziness;

• nausea, vomiting;

• feeling hot or cold;

• confusion, ringing in your ears, blurred vision, double vision; or

• numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xylocaine HCl?

Tell your doctor about all your other medicines, especially:

• cimetidine, fluvoxamine, nefazodone, St John''s wort;

• antibiotic or antifungal medicine;

• antiviral medicine to treat hepatitis or HIV/AIDS;

• heart or blood pressure medicine--amiodarone, digoxin, nicardipine, procainamide, propranolol;

• seizure medicine--carbamazepine, phenytoin; or

• tuberculosis medicine--isoniazid, rifampin.

This list is not complete. Other drugs may affect lidocaine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 4.01.

Generic name: lidocaine (injection route) [ LYE-doe-kane ]
Drug classes: Group I antiarrhythmics, Local injectable anesthetics

Medically reviewed by Drugs.com. Last updated on Jan 4, 2023.

Commonly used brand name(s)

In the U.S.

• Xylocaine
• Xylocaine-MPF

Available Dosage Forms:

• Solution

Therapeutic Class: Anesthetic, Local

Chemical Class: Amino Amide

Uses for Xylocaine

Lidocaine injection is used to cause numbness or loss of feeling for patients having certain medical procedures (by blocking certain nerves using the brachial plexus, intercostal, lumbar, or epidural blocking techniques). Lidocaine is a local anesthetic. It prevents pain by blocking the signals at the nerve endings in the skin. This medicine does not cause unconsciousness as general anesthetics do when used for surgery.

This medicine is to be given only by or under the direct supervision of your doctor.

Before using Xylocaine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Because of this medicine''s toxicity, it should be used with extreme caution in children younger than 6 months of age. Recommended doses should not be exceeded, and the patient should be carefully monitored during treatment.

Geriatric

No information is available on the relationship of age to the effects of lidocaine injection in geriatric patients. However, because of this medicine''s toxicity, it should be used with caution. Recommended doses should not be exceeded, and the patient should be carefully monitored during treatment.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Dihydroergotamine
• Dronedarone
• Saquinavir
• Vernakalant

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amifampridine
• Amiodarone
• Amprenavir
• Arbutamine
• Atazanavir
• Bupivacaine
• Bupivacaine Liposome
• Bupropion
• Cobicistat
• Dasabuvir
• Delavirdine
• Disopyramide
• Donepezil
• Encainide
• Etravirine
• Flecainide
• Fosamprenavir
• Fosphenytoin
• Fospropofol
• Hyaluronidase
• Lacosamide
• Lopinavir
• Metoprolol
• Mexiletine
• Moricizine
• Nadolol
• Ombitasvir
• Paritaprevir
• Phenytoin
• Procainamide
• Propafenone
• Propofol
• Propranolol
• Quinidine
• Sotalol
• St John''s Wort
• Succinylcholine
• Telaprevir
• Tocainide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cimetidine
• Penbutolol

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood vessel disease or
• Heart disease or
• Hypertension (high blood pressure) or
• Liver disease—Use with caution. The chance of side effects may be increased.

• Brain or nerve disease or
• Heart block or
• Hypertension (high blood pressure), severe or
• Sepsis or
• Shock, severe or
• Spine problems—Use with caution.

• Glucose-6-phosphate dehydrogenase deficiency (G6PD) or
• Heart problems or
• Lung or breathing problems or
• Methemoglobinemia (blood disorder), hereditary or idiopathic (unknown cause)—Use with caution. May increase risk of having methemoglobinemia.

Proper use of Xylocaine

This section provides information on the proper use of a number of products that contain lidocaine. It may not be specific to Xylocaine. Please read with care.

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins, into your upper arm, into the head and neck area, or into the space around the spinal nerves in your lower back.

Precautions while using Xylocaine

It is very important that your doctor check you or your child''s progress closely while you are receiving this medicine to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause a rare, but serious blood problem called methemoglobinemia. The risk may be increased in children younger than 6 months of age, elderly patients, or patients with certain inborn defects. It is more likely to occur in patients receiving too much of the medicine, but can also occur with small amounts. Check with your doctor right away if you or your child has the following symptoms after receiving this medicine: pale, gray, or blue-colored skin, lips, or nails, confusion, headache, lightheadedness, fast heartbeat, or unusual tiredness or weakness.

If you receive this medicine into your lower back (epidural), you may experience temporary loss of sensation and movement, usually in the lower half of your body. Talk with your doctor if you have concerns.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Xylocaine side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Bluish-colored lips, fingernails, or palms blurred or double vision
• chest pain or discomfort
• cold, clammy, pale skin
• confusion
• continuing ringing or buzzing or other unexplained noise in the ears
• cough
• dark urine
• difficulty breathing
• difficulty swallowing
• dizziness or lightheadedness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• fast heartbeat
• fever
• headache
• hearing loss
• hives, itching, skin rash
• irregular heartbeat
• irregular, fast or slow, or shallow breathing
• loss of consciousness
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid or slow heart rate
• seizures
• slow or irregular heartbeat
• sore throat
• sweating
• tightness in the chest
• tremor
• twitching
• unusual bleeding or bruising
• unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Cold or numb feeling
• false or unusual sense of well-being
• feeling of heat
• loss of bladder and bowel control
• loss of genital sensation and sexual function
• nervousness
• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer